About: Alpha-tocopherol in lipoprotein apheresis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Prospective clinical study of the mutual interactions and particular role of fundamental lipid related atherogenic mechanisms in patients with severe hypercholesterolemia treated by low density lipoprotein apheresis. Project will investigate changes and correlation of the i) cholesterol biosynthetic pathway and its intermediary products, metabolism and absorption, ii) plasma and cell membrane unsaturated and saturated fatty acids. Futher examination will focus on iii) lipoperoxidation processes and antioxidant consumption. The results might improve our knowledge and thus treatment of atherosclerosis, which is the leading cause of morbidity and mortality in Czech Republic. (en) Prospektivní klinická studie vzájemné interakce a úlohy nejdůležitějších lipidových aterogenních mechanismů u pacientů se závažnou hypercholesterolémií, léčených LDL (low density lipoprotein) aferézou. Projekt, který navazuje na předchozí výsledky řešitelského týmu, bude zkoumat změny a korelace následujících parametrů: i) biosyntéza cholesterolu a jeho intermediárních produktů. Další analýza bude hodnotit ii) nenasycené a nasycené mastné kyseliny v plasmě a buněčné membráně, iii) průběh lipoperoxidace a konsumpce antioxidantů. Získané poznatky mohou přispět k objasnění a tím i k léčbě procesu aterosklerózy, která je nejčastější příčinou morbidity a mortality v České republice. (cs) Prospective clinical study of the mutual interactions and particular role of fundamental lipid related atherogenic mechanisms in patients with severe hypercholesterolemia treated by low density lipoprotein apheresis. Project will investigate changes and correlation of the i) cholesterol biosynthetic pathway and its intermediary products, metabolism and absorption, ii) plasma and cell membrane unsaturated and saturated fatty acids. Futher examination will focus on iii) lipoperoxidation processes and antioxidant consumption. The results might improve our knowledge and thus treatment of atherosclerosis, which is the leading cause of morbidity and mortality in Czech Republic.
Title	Alpha-tocopherol in lipoprotein apheresis Alfa-tokoferol u LDL-aferézy (cs) Alpha-tocopherol in lipoprotein apheresis (en)
skos:prefLabel	Alpha-tocopherol in lipoprotein apheresis Alfa-tokoferol u LDL-aferézy (cs) Alpha-tocopherol in lipoprotein apheresis (en)
skos:notation	RIV/00216208:11150/07:00003501!RIV08-MZ0-11150___
http://linked.open.../vavai/riv/strany	617;623
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR8062)
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Bláha, Milan Zadák, Zdeněk Bláha, Vladimír Žďánský, Petr
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	464629
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/07:00003501
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	apoB; apolipoprotein B; HDL; high-density lipoprotein; IDL; intermediate-density lipoprotein; LDL; low-density lipoprotein; VLDL; very low-density lipoprotein (en)
http://linked.open.../riv/klicoveSlovo	apoB apolipoprotein B intermediate-density lipoprotein very low-density lipoprotein high-density lipoprotein IDL HDL VLDL LDL low-density lipoprotein
http://linked.open...ontrolniKodProRIV	[D55EE69D8B3C]
http://linked.open...i/riv/mistoVydani	Oxfordshire
http://linked.open...vEdiceCisloSvazku	encyklopedie
http://linked.open...i/riv/nazevZdroje	The Encyclopedia of Vitamin E
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Unstable ateromatous plaque: the possibilities to influence the prognosis of clinically important organ atherosclerosis
http://linked.open...UplatneniVysledku	2007
http://linked.open...iv/tvurceVysledku	Bláha, Milan Zadák, Zdeněk Bláha, Vladimír Žďánský, Petr
number of pages	7 (xsd:int)
http://purl.org/ne...btex#hasPublisher	CABI Publishing
https://schema.org/isbn	978-1-84593-075-2
http://localhost/t...ganizacniJednotka	11150
is http://linked.open...avai/riv/vysledek of	Alpha-tocopherol in lipoprotein apheresis Alpha-tocopherol in lipoprotein apheresis

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