About: HPLC determination of a novel aroylhydrazone iron chelator (o-108) in rabbit plasma and its application to a pilot pharmacokinetic study

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About: HPLC determination of a novel aroylhydrazone iron chelator (o-108) in rabbit plasma and its application to a pilot pharmacokinetic study Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this study a high performance liquid chromatographic method for the determination of a biocompatible iron chelator, pyridoxal 2-chlorobenzoyl hydrazone (o-108), in rabbit plasma was developed and validated. The separation was achieved on a C18 column with the mobile phase composed of a mixture of 0.01 M phosphate buffer (pH 6) with the addition of EDTA (2 mM), methanol and acetonitrile (42:24:14; v/v/v). This method was successfully applied to the analysis of the samples obtained from a pilot pharmacokinetic experiment, in which the chelator was administered intravenously to rabbits. In this study a high performance liquid chromatographic method for the determination of a biocompatible iron chelator, pyridoxal 2-chlorobenzoyl hydrazone (o-108), in rabbit plasma was developed and validated. The separation was achieved on a C18 column with the mobile phase composed of a mixture of 0.01 M phosphate buffer (pH 6) with the addition of EDTA (2 mM), methanol and acetonitrile (42:24:14; v/v/v). This method was successfully applied to the analysis of the samples obtained from a pilot pharmacokinetic experiment, in which the chelator was administered intravenously to rabbits. (en) V této studii byla vyvinuta a validována HPLC metoda pro stanovení biokompatibilního chelátoru železa pyridoxal 2-chlorbenzoylhydrazonu v králičí plasmě. Separace bylo dosaženo na C18 koloně s mobilní fází skládající se ze směsi fosfátového pufru (0,01 M, pH 6) s přídavkem EDTA (2 mM), methanolu a acetonitrilu (42:24:14; v/v/v). Tato metoda byla úspěšně aplikována do analýzy vzorků získaných z pilotního farmakokinetického experimentu, v kterém byl chelátor podáván intravenózně králíkům. (cs)
Title	HPLC determination of a novel aroylhydrazone iron chelator (o-108) in rabbit plasma and its application to a pilot pharmacokinetic study HPLC determination of a novel aroylhydrazone iron chelator (o-108) in rabbit plasma and its application to a pilot pharmacokinetic study (en) HPLC stanovení nového aroylhydrazonového chelátoru (o-108) v králičí plasmě a jeho aplikace do pilotního farmakokinetické studie (cs)
skos:prefLabel	HPLC determination of a novel aroylhydrazone iron chelator (o-108) in rabbit plasma and its application to a pilot pharmacokinetic study HPLC determination of a novel aroylhydrazone iron chelator (o-108) in rabbit plasma and its application to a pilot pharmacokinetic study (en) HPLC stanovení nového aroylhydrazonového chelátoru (o-108) v králičí plasmě a jeho aplikace do pilotního farmakokinetické studie (cs)
skos:notation	RIV/00216208:11150/06:00004336!RIV07-MSM-11150___
http://linked.open.../vavai/riv/strany	107;112
http://linked.open...avai/riv/aktivita	V Z
http://linked.open...avai/riv/aktivity	V, Z(MSM0021620820), Z(MSM0021620822)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Geršl, Vladimír Štěrba, Martin Popelová, Olga
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	478306
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/06:00004336
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HPLC; pyridoxal 2-chlorobenzoyl hydrazone; iron chelator; pharmacokinetics (en)
http://linked.open.../riv/klicoveSlovo	HPLC pharmacokinetics iron chelator pyridoxal 2-chlorobenzoyl hydrazone
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[9B7E560EF761]
http://linked.open...i/riv/nazevZdroje	Journal of Chromatography B
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	838
http://linked.open...iv/tvurceVysledku	Geršl, Vladimír Popelová, Olga Štěrba, Martin
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement Research of new drug structures
issn	1570-0232
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	11150
is http://linked.open...avai/riv/vysledek of	HPLC determination of a novel aroylhydrazone iron chelator (o-108) in rabbit plasma and its application to a pilot pharmacokinetic study HPLC determination of a novel aroylhydrazone iron chelator (o-108) in rabbit plasma and its application to a pilot pharmacokinetic study

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