About: Low-dose methotrexate pharmacokinetics and pharmacodynamics in the therapy of severe psoriasis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	41 patients with psoriasis were treated with 7,5 mg or 15 mg MTX administered once a week. The pharmacokinetic of MTX were evaluated at week 1 and 13, MTX in erythrocytes and the PASI-score were evaluated repeatedly. There was a strong correlation between MTX AUC at week 1 and PASI at week 13 (rho = -0,08, p 0,0001). 41 patients with psoriasis were treated with 7,5 mg or 15 mg MTX administered once a week. The pharmacokinetic of MTX were evaluated at week 1 and 13, MTX in erythrocytes and the PASI-score were evaluated repeatedly. There was a strong correlation between MTX AUC at week 1 and PASI at week 13 (rho = -0,08, p 0,0001). (en) Nemocní s těžkou psoriázou (N = 41) byly léčeni MTX v nízkých dávkách (7,5 nebo 15 mg) 1x týdně. Farmakokinetika MTX, jeho koncentrace v erytrocytech a klinický stav (skore PASI) byly hodnoceny opakovaně v průběhu prvních 13ti týdnů. Byla nalezena vysoce signifikantní korelace mezi AUCMTX v prvním týdnu a stavem onemocnění kůže ve třináctém týdnu (PASI) (rho = -0,08, p 0,0001) (cs)
Title	Low-dose methotrexate pharmacokinetics and pharmacodynamics in the therapy of severe psoriasis Farmakokinetika a farmakodynamika nízkých dávek metotrexátu v léčbě těžké psoriázy (cs) Low-dose methotrexate pharmacokinetics and pharmacodynamics in the therapy of severe psoriasis (en)
skos:prefLabel	Low-dose methotrexate pharmacokinetics and pharmacodynamics in the therapy of severe psoriasis Farmakokinetika a farmakodynamika nízkých dávek metotrexátu v léčbě těžké psoriázy (cs) Low-dose methotrexate pharmacokinetics and pharmacodynamics in the therapy of severe psoriasis (en)
skos:notation	RIV/00216208:11150/05:00003501!RIV06-MSM-11150___
http://linked.open.../vavai/riv/strany	247;248
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(1P04OCB15.10)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Chládek, Jaroslav Grim, Jiří Martínková, Jiřina Vaněčková, Jaroslava Šimková, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	528476
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/05:00003501
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	methotrexate; psoriasis; pharmacokinetics (en)
http://linked.open.../riv/klicoveSlovo	pharmacokinetics psoriasis methotrexate
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[2F8860B0B75F]
http://linked.open...i/riv/nazevZdroje	Basic and Clinical Pharmacology and Toxicology
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Population modelling of wanted and unwanted clinical outcomes and surrogate parameters
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	96
http://linked.open...iv/tvurceVysledku	Chládek, Jaroslav Vaněčková, Jaroslava Grim, Jiří Martínková, Jiřina Šimková, Marie
issn	1742-7835
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	11150
is http://linked.open...avai/riv/vysledek of	Low-dose methotrexate pharmacokinetics and pharmacodynamics in the therapy of severe psoriasis

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