About: Mutations in the Ki-ras Gene Detected in Colorectal Biopsy Specimens     Goto   Sponge   NotDistinct   Permalink

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Description
  • Cíl: Somatické mutace v Ki-ras genu jsou považovány za důležitý patogenetický jev, objevující se přibližně uprostřed neoplastické kaskády tlustého střeva. Tyto genetické změny byly pozorovány u zhruba 40% vyjmutých kolorektálních karcinomů a u 20% benigních střevních adenomů. V této studii jsme analyzovali přítomnost mutací Ki-Ras genu v bioptických vzorcích kolorektálních nádorů a polypů. Při zohlednění agresivity některých Ki-ras mutací, patřičná analýza DNA by mohly přispět ke zlepšení laboratorní diagnostiky rakoviny, zvláště u subjektů se zvýšeným rizikem kolorektálního karcinomu. (cs)
  • Objective: Somatic mutations in the Ki-ras gene are believed to be an important pathogenetic event occurring approximately in the middle of the neoplastic cascade in the colon. These genetic changes have been observed in about 40%of resected colorectal carcinomas and in 20–60%of benign colon adenomas. In this studywe analyzed the presence of Ki-ras gene mutations in bioptic specimens of colorectal tumours and polyps.Conclusion: Taking into account aggressivity of some Ki-ras mutations, a proper DNA analysis could contribute to improvement of laboratory diagnostics of cancer, especially in subjects at a higher risk for colorectal carcinoma.
  • Objective: Somatic mutations in the Ki-ras gene are believed to be an important pathogenetic event occurring approximately in the middle of the neoplastic cascade in the colon. These genetic changes have been observed in about 40%of resected colorectal carcinomas and in 20–60%of benign colon adenomas. In this studywe analyzed the presence of Ki-ras gene mutations in bioptic specimens of colorectal tumours and polyps.Conclusion: Taking into account aggressivity of some Ki-ras mutations, a proper DNA analysis could contribute to improvement of laboratory diagnostics of cancer, especially in subjects at a higher risk for colorectal carcinoma. (en)
Title
  • Mutations in the Ki-ras Gene Detected in Colorectal Biopsy Specimens
  • Mutations in the Ki-ras Gene Detected in Colorectal Biopsy Specimens (en)
  • Mutace genu Ki-ras zachycené ve vzorcích z kolorektální biopsie (cs)
skos:prefLabel
  • Mutations in the Ki-ras Gene Detected in Colorectal Biopsy Specimens
  • Mutations in the Ki-ras Gene Detected in Colorectal Biopsy Specimens (en)
  • Mutace genu Ki-ras zachycené ve vzorcích z kolorektální biopsie (cs)
skos:notation
  • RIV/00216208:11150/04:00004662!RIV08-MSM-11150___
http://linked.open.../vavai/riv/strany
  • 97;100
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 575111
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11150/04:00004662
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Mutations; Ki-ras; Detected; Colorectal; Biopsy; Specimens (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [2EF4A1B1F49B]
http://linked.open...i/riv/nazevZdroje
  • Klinická biochemie a metabolismus
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 12
http://linked.open...iv/tvurceVysledku
  • Beránek, Martin
  • Bureš, Jan
  • Palička, Vladimír
  • Dědič, Karel
issn
  • 1210-7921
number of pages
http://localhost/t...ganizacniJednotka
  • 11150
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