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| rdf:type
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| Description
| - Selhání apoptózy při léčbě hemoblastózy cytostatiky je jednou z příčin chemorezistence. Zajímali jsme se o vztah apoptózy AML buněk po podání doxorubicinu a imunofenotypem, vybranými klinickými a laboratorními parametry a expresí proteinů P-gp, MRP, LRP, Bcl-2 a Bax. Všechny analýzy byly hodnoceny metodou průtokové cytometrie. K detekci apoptotických buněk ve vzorku byly použity 3 metody: annexin test, TUNEL (TdT-mediated dUTP nick end labeling) test a detekce kaspázy 8. Po kultivaci buněk byl zřejmý statistický nárůst apoptotických buněk v kultuře. Byl také pozorován vztah mezi in vitro blastickou reakcí AML buněk a některými klinickými parametry jako věk pacienta, počet bílých krvinek a procento blastických buněk (cs)
- The apoptosis failure in cytostatic treatment of haemoblastosis is one of the means of chemoresistance. We were interested in the relationship of the after-doxorubicin-treatment-AML cells apoptosis and the immunophenotype, selected clinical and laboratory parameters, and also the P-gp, MRP, LRP, Bcl-2, Bax proteins expression. All analysis were evaluated with the flow cytometry method. To detect apoptotic cells in the sample, we used three methods: annexin test, TUNEL (TdT-mediated dUTP nick end labeling) test, and caspase 8 detection. After the cell cultivation the statisticaly important increase of apoptotic cells in the culture was apparent. The relation between the AML blast in vitro reaction and some clinical parameters such as the age of patient, white blood cell count, and blast percentage was also observed. : AML; Apoptosis; Multidrug resistance; Flow cytometry
- The apoptosis failure in cytostatic treatment of haemoblastosis is one of the means of chemoresistance. We were interested in the relationship of the after-doxorubicin-treatment-AML cells apoptosis and the immunophenotype, selected clinical and laboratory parameters, and also the P-gp, MRP, LRP, Bcl-2, Bax proteins expression. All analysis were evaluated with the flow cytometry method. To detect apoptotic cells in the sample, we used three methods: annexin test, TUNEL (TdT-mediated dUTP nick end labeling) test, and caspase 8 detection. After the cell cultivation the statisticaly important increase of apoptotic cells in the culture was apparent. The relation between the AML blast in vitro reaction and some clinical parameters such as the age of patient, white blood cell count, and blast percentage was also observed. : AML; Apoptosis; Multidrug resistance; Flow cytometry (en)
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| Title
| - Hodnocení mnohočetné lékové rezistence u buněk akutní myeloidní leukémie po ošetření doxorubicinem in vitro (cs)
- The multidrug resistance and apoptosis evaluation in acute myeloid leukemia cells after the in vitro doxorubicin treatment
- The multidrug resistance and apoptosis evaluation in acute myeloid leukemia cells after the in vitro doxorubicin treatment (en)
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| skos:prefLabel
| - Hodnocení mnohočetné lékové rezistence u buněk akutní myeloidní leukémie po ošetření doxorubicinem in vitro (cs)
- The multidrug resistance and apoptosis evaluation in acute myeloid leukemia cells after the in vitro doxorubicin treatment
- The multidrug resistance and apoptosis evaluation in acute myeloid leukemia cells after the in vitro doxorubicin treatment (en)
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| skos:notation
| - RIV/00216208:11150/04:00004429!RIV08-MSM-11150___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11150/04:00004429
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - multidrug; resistance; apoptosis; evaluation; acute; myeloid; leukemia; cells; after; vitro; doxorubicin; treatment (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Acta Medica (Hradec Králové)
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Krejsek, Jan
- Novosad, Jakub
- Kopecký, Otakar
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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