About: Effect of irinotecan on phenotype of peripheral blood leukocyte populations in patients metastatic colorectal cancer     Goto   Sponge   NotDistinct   Permalink

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Description
  • CD3+CD4+lymphocytopenia, a decrease in CD8+CD28+ and CD19+lymphocytes, increased expression of activation markers and CD14+CD16+monocytosis are present in a significant proportion of metastatic colorectal cancer patients. CPT-11-based therapy seems to ameliorate CD3+CD4+lymphocytopenia, possibly by neutralizing the immunosuppressive effects of uncontrolled tumor growth. These observation may be useful for the design of immunotherapy trials in metastatic colorectal cancer.
  • CD3+CD4+lymphocytopenia, a decrease in CD8+CD28+ and CD19+lymphocytes, increased expression of activation markers and CD14+CD16+monocytosis are present in a significant proportion of metastatic colorectal cancer patients. CPT-11-based therapy seems to ameliorate CD3+CD4+lymphocytopenia, possibly by neutralizing the immunosuppressive effects of uncontrolled tumor growth. These observation may be useful for the design of immunotherapy trials in metastatic colorectal cancer. (en)
Title
  • Effect of irinotecan on phenotype of peripheral blood leukocyte populations in patients metastatic colorectal cancer
  • Effect of irinotecan on phenotype of peripheral blood leukocyte populations in patients metastatic colorectal cancer (en)
skos:prefLabel
  • Effect of irinotecan on phenotype of peripheral blood leukocyte populations in patients metastatic colorectal cancer
  • Effect of irinotecan on phenotype of peripheral blood leukocyte populations in patients metastatic colorectal cancer (en)
skos:notation
  • RIV/00216208:11150/02:00001072!RIV/2003/MSM/111503/N
http://linked.open.../vavai/riv/strany
  • 967;970
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 111500002)
http://linked.open...iv/cisloPeriodika
  • 49
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 644233
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11150/02:00001072
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • irinotecan; colorectal cancer; lymphocytes subpopulations (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [7CC423687EDC]
http://linked.open...i/riv/nazevZdroje
  • Hepato-Gastroenterology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...ocetUcastnikuAkce
http://linked.open...nichUcastnikuAkce
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 46
http://linked.open...iv/tvurceVysledku
  • Melichar, Bohuslav
http://linked.open...n/vavai/riv/zamer
issn
  • 0172-6390
number of pages
http://localhost/t...ganizacniJednotka
  • 11150
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