About: Fate of two types of cerebellar graft in wild type and cerebellar mutant mice

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S1214021X13000021#
Description	The possibility of regeneration in a damaged central nervous system (CNS) is limited and therapy of CNS diseases accompanied with neuronal loss is problematic. Neurotransplantation-based therapies have a great potential for future treatments of various diseases, not only by replacing missing or malfunctioning cells but mainly by supporting the inner regenerative processes. Lurcher (Lc) mutant mice represent a model for olivocerebellar degeneration. Heterozygotes suffer from a complete loss of cerebellar Purkinje cells and a secondary reduction of granule cells and inferior olive neuron number. The aim of this study was to analyze the survival potential and appearance of grafted GFP-positive carcinoma stem cells partially differentiated into neuroprogenitors from the P19 line or cerebellar embryonic tissue (in the form of cell suspension) both transplanted into the cerebellum of Lurcher mutant and healthy control wild type mice. The possibility of regeneration in a damaged central nervous system (CNS) is limited and therapy of CNS diseases accompanied with neuronal loss is problematic. Neurotransplantation-based therapies have a great potential for future treatments of various diseases, not only by replacing missing or malfunctioning cells but mainly by supporting the inner regenerative processes. Lurcher (Lc) mutant mice represent a model for olivocerebellar degeneration. Heterozygotes suffer from a complete loss of cerebellar Purkinje cells and a secondary reduction of granule cells and inferior olive neuron number. The aim of this study was to analyze the survival potential and appearance of grafted GFP-positive carcinoma stem cells partially differentiated into neuroprogenitors from the P19 line or cerebellar embryonic tissue (in the form of cell suspension) both transplanted into the cerebellum of Lurcher mutant and healthy control wild type mice. (en)
Title	Fate of two types of cerebellar graft in wild type and cerebellar mutant mice Fate of two types of cerebellar graft in wild type and cerebellar mutant mice (en)
skos:prefLabel	Fate of two types of cerebellar graft in wild type and cerebellar mutant mice Fate of two types of cerebellar graft in wild type and cerebellar mutant mice (en)
skos:notation	RIV/00216208:11140/14:10156021!RIV15-MSM-11140___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(ED2.1.00/03.0076), P(EE2.3.30.0022), P(LD12057), S
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Vožeh, František Čedíková, Miroslava Králíčková, Milena Kulda, Vlastimil Krakorová, Kristýna Houdek, Zbyněk Cendelín, Jan Babuška, Václav Černá, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Plzni
http://linked.open...dnocenehoVysledku	16527
http://linked.open...ai/riv/idVysledku	RIV/00216208:11140/14:10156021
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Graft survival; Intracerebellar application; Naive P19 cells; P19-derived neuroprogenitors (en)
http://linked.open.../riv/klicoveSlovo	Graft survival P19-derived neuroprogenitors Intracerebellar application Naive P19 cells
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[D8A9F622BF74]
http://linked.open...i/riv/nazevZdroje	Journal of Applied Biomedicine
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Sonic hedgehog treatment effect on functional manifestation of an embryonic stem cell graft in Lurcher mice Biomedical Centre of the Faculty of Medicine in Pilsen Support of establishment, development, and mobility of quality research teams at the Charles University
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Houdek, Zbyněk Černá, Lenka Králíčková, Milena Vožeh, František Čedíková, Miroslava Kulda, Vlastimil Krakorová, Kristýna Babuška, Václav Cendelín, Jan Zech, Nicolas
http://linked.open...ain/vavai/riv/wos	000333504400002
issn	1214-021X
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jab.2013.03.001
http://localhost/t...ganizacniJednotka	11140

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