About: Double Product Reflects the Predictive Power of Systolic Pressure in the General Population: Evidence from 9,937 Participants

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1093/ajh/hps119
Description	BACKGROUND The double product (DP), consisting of the systolic blood pressure (SBP) multiplied by the pulse rate (PR), is an index of myocardial oxygen consumption, but its prognostic value in the general population remains unknown. METHODS We recorded health outcomes in 9,937 subjects (median age, 53.2 years; 47.3% women) randomly recruited from 11 populations and enrolled in the International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) study. We obtained the SBP, PR, and DP for these subjects as determined through 24-hour ambulatory monitoring. RESULTS Over a median period of 11.0 years, 1,388 of the 9,937 study subjects died, of whom 536 and 794, respectively, died of cardiovascular (CV) and non-CV causes, and a further 1,161, 658, 494, and 465 subjects, respectively, experienced a CV, cardiac, coronary, or cerebrovascular event. In multivariate-adjusted Cox models, not including SBP and PR, DP predicted total, CV, and non-CV mortality (standardized hazard ratio [HR], }= 1.10; P {= 0.02), and all CV, cardiac, coronary, and stroke events (HR, }= 1.21; P < 0.0001). For CV mortality (HR, 1.34 vs. 1.30; P = 0.71) and coronary events (1.28 vs. 1.21; P = 0.26), SBP and the DP were equally predictive. As compared with DP, SBP was a stronger predictor of all CV events (1.39 vs. 1.27; P = 0.002) and stroke (1.61 vs. 1.36; P < 0.0001), and a slightly stronger predictor of cardiac events (1.32 vs. 1.22; P = 0.06). In fully adjusted models, including both SBP and PR, the predictive value of DP disappeared for fatal endpoints (P }= 0.07), coronary events (P = 0.06), and stroke (P = 0.12), or DP was even inversely associated with the risk of all CV and cardiac events (both P {= 0.01). CONCLUSION In the general population, we did not observe DP to add to risk stratification over and beyond SBP and PR. BACKGROUND The double product (DP), consisting of the systolic blood pressure (SBP) multiplied by the pulse rate (PR), is an index of myocardial oxygen consumption, but its prognostic value in the general population remains unknown. METHODS We recorded health outcomes in 9,937 subjects (median age, 53.2 years; 47.3% women) randomly recruited from 11 populations and enrolled in the International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) study. We obtained the SBP, PR, and DP for these subjects as determined through 24-hour ambulatory monitoring. RESULTS Over a median period of 11.0 years, 1,388 of the 9,937 study subjects died, of whom 536 and 794, respectively, died of cardiovascular (CV) and non-CV causes, and a further 1,161, 658, 494, and 465 subjects, respectively, experienced a CV, cardiac, coronary, or cerebrovascular event. In multivariate-adjusted Cox models, not including SBP and PR, DP predicted total, CV, and non-CV mortality (standardized hazard ratio [HR], }= 1.10; P {= 0.02), and all CV, cardiac, coronary, and stroke events (HR, }= 1.21; P < 0.0001). For CV mortality (HR, 1.34 vs. 1.30; P = 0.71) and coronary events (1.28 vs. 1.21; P = 0.26), SBP and the DP were equally predictive. As compared with DP, SBP was a stronger predictor of all CV events (1.39 vs. 1.27; P = 0.002) and stroke (1.61 vs. 1.36; P < 0.0001), and a slightly stronger predictor of cardiac events (1.32 vs. 1.22; P = 0.06). In fully adjusted models, including both SBP and PR, the predictive value of DP disappeared for fatal endpoints (P }= 0.07), coronary events (P = 0.06), and stroke (P = 0.12), or DP was even inversely associated with the risk of all CV and cardiac events (both P {= 0.01). CONCLUSION In the general population, we did not observe DP to add to risk stratification over and beyond SBP and PR. (en)
Title	Double Product Reflects the Predictive Power of Systolic Pressure in the General Population: Evidence from 9,937 Participants Double Product Reflects the Predictive Power of Systolic Pressure in the General Population: Evidence from 9,937 Participants (en)
skos:prefLabel	Double Product Reflects the Predictive Power of Systolic Pressure in the General Population: Evidence from 9,937 Participants Double Product Reflects the Predictive Power of Systolic Pressure in the General Population: Evidence from 9,937 Participants (en)
skos:notation	RIV/00216208:11140/13:10140200!RIV14-MSM-11140___
http://linked.open...avai/predkladatel	Lékařská fakulta v Plzni
http://linked.open...avai/riv/aktivita	R
http://linked.open...avai/riv/aktivity	R
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Filipovský, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Plzni
http://linked.open...dnocenehoVysledku	70508
http://linked.open...ai/riv/idVysledku	RIV/00216208:11140/13:10140200
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	general population; hypertension; cardiovascular risk; systolic blood pressure; double product; blood pressure (en)
http://linked.open.../riv/klicoveSlovo	general population hypertension - ischaemic heart disease - cardiac failure - vitamin D double product systolic blood pressure blood pressure cardiovascular risk
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[DB609ECEEBC7]
http://linked.open...i/riv/nazevZdroje	American Journal of Hypertension
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	28 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	26
http://linked.open...iv/tvurceVysledku	Filipovský, Jan Casiglia, Edoardo Kawecka-Jaszcz, Kalina Kuznetsova, Tatiana Malyutina, Sofia Nikitin, Yuri Staessen, Jan A. Stolarz-Skrzypek, Katarzyna Thijs, Lutgarde Tikhonoff, Valerie Li, Yan Asayama, Kei Bjorklund-Bodegard, Kristina Boggia, Jose Dolan, Eamon Hansen, Tine W. Ibsen, Hans Imai, Yutaka Jeppesen, Jorgen Kikuya, Masahiro Lind, Lars Liu, Yan-Ping O'Brien, Eoin Ohkubo, Takayoshi Sandoya, Edgardo Schutte, Rudolph Torp-Pedersen, Christian Wang, Jiguang
http://linked.open...ain/vavai/riv/wos	000317320300011
issn	0895-7061
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1093/ajh/hps119
http://localhost/t...ganizacniJednotka	11140

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