About: Lurcher Mouse

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://link.springer.com/content/pdf/bfm%3A978-94-007-1333-8%2F1.pdf
Description	Lurcher mutant mice represent one of the frequently used mouse models of the olivocerebellar degeneration. It is caused by a mutation in the δ2 glutamate receptor subunit encoding gene. The gain of function mutation changes the receptor into a leaky membrane channel leading to chronic depolarization of the cells expressing the receptor. Heterozygous Lurcher mice suffer from virtually complete postnatal loss of cerebellar Purkinje cells and reduction of granule, stellate and basket cells and inferior olive neurons and relatively mild changes in the deep cerebellar nuclei. The death of Purkinje cells is a primary effect of the mutation and it shows features of apoptosis, autophagy and necrosis. Extinction of the granule, stellate and basket cells and inferior olive neurons is a target-related cell death. Lurcher mice display neurochemical and metabolic changes, abnormalities in the neurotransmitter and receptor systems, endocrine and immune abnormalities and multiple behavioral deficits. Lurcher mutant mice represent one of the frequently used mouse models of the olivocerebellar degeneration. It is caused by a mutation in the δ2 glutamate receptor subunit encoding gene. The gain of function mutation changes the receptor into a leaky membrane channel leading to chronic depolarization of the cells expressing the receptor. Heterozygous Lurcher mice suffer from virtually complete postnatal loss of cerebellar Purkinje cells and reduction of granule, stellate and basket cells and inferior olive neurons and relatively mild changes in the deep cerebellar nuclei. The death of Purkinje cells is a primary effect of the mutation and it shows features of apoptosis, autophagy and necrosis. Extinction of the granule, stellate and basket cells and inferior olive neurons is a target-related cell death. Lurcher mice display neurochemical and metabolic changes, abnormalities in the neurotransmitter and receptor systems, endocrine and immune abnormalities and multiple behavioral deficits. (en)
Title	Lurcher Mouse Lurcher Mouse (en)
skos:prefLabel	Lurcher Mouse Lurcher Mouse (en)
skos:notation	RIV/00216208:11140/13:10134173!RIV14-MSM-11140___
http://linked.open...avai/predkladatel	Lékařská fakulta v Plzni
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Vožeh, František Cendelín, Jan
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Plzni
http://linked.open...dnocenehoVysledku	85598
http://linked.open...ai/riv/idVysledku	RIV/00216208:11140/13:10134173
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Purkinje cell; olivocerebellar degeneration; Lurcher mouse (en)
http://linked.open.../riv/klicoveSlovo	Lurcher mouse Purkinje cell olivocerebellar degeneration
http://linked.open...ontrolniKodProRIV	[D846AFB75EFD]
http://linked.open...i/riv/mistoVydani	New York
http://linked.open...vEdiceCisloSvazku	Neuveden
http://linked.open...i/riv/nazevZdroje	Handbook of the Cerebellum and Cerebellar Disorders
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...v/pocetStranKnihy	2424 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Vožeh, František Cendelín, Jan
number of pages	22 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/978-94-007-1333-8
http://purl.org/ne...btex#hasPublisher	Springer New York LLC
https://schema.org/isbn	978-94-007-1333-8
http://localhost/t...ganizacniJednotka	11140

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