About: Adult Height in Patients with Advanced CKD Requiring Renal Replacement Therapy during Childhood     Goto   Sponge   NotDistinct   Permalink

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Description
  • Background and objectivesGrowth and final height are of major concern in children with ESRD. This study sought to describe the distribution of adult height of patients who started renal replacement therapy (RRT) during childhood and to identify determinants of final height in a large cohort of RRT children.Design, setting, participants, & measurementsA total of 1612 patients from 20 European countries who started RRT before 19 years of age and reached final height between 1990 and 2011 were included. Linear regression analyses were performed to calculate adjusted mean final height SD score (SDS) and to investigate its potential determinants.ResultsThe median final height SDS was -1.65 (median of 168 cm in boys and 155 cm in girls). Fifty-five percent of patients attained an adult height within the normal range. Adjusted for age at start of RRT and primary renal diseases, final height increased significantly over time from -2.06 SDS in children who reached adulthood in 1990-1995 to -1.33 SDS among those reaching adulthood in 2006-2011. Older age at start of RRT, more recent period of start of RRT, cumulative percentage time on a functioning graft, and greater height SDS at initiation of RRT were independently associated with a higher final height SDS. Patients with congenital anomalies of the kidney and urinary tract and metabolic disorders had a lower final height than those with other primary renal diseases.ConclusionsAlthough final height remains suboptimal in children with ESRD, it has consistently improved over time.
  • Background and objectivesGrowth and final height are of major concern in children with ESRD. This study sought to describe the distribution of adult height of patients who started renal replacement therapy (RRT) during childhood and to identify determinants of final height in a large cohort of RRT children.Design, setting, participants, & measurementsA total of 1612 patients from 20 European countries who started RRT before 19 years of age and reached final height between 1990 and 2011 were included. Linear regression analyses were performed to calculate adjusted mean final height SD score (SDS) and to investigate its potential determinants.ResultsThe median final height SDS was -1.65 (median of 168 cm in boys and 155 cm in girls). Fifty-five percent of patients attained an adult height within the normal range. Adjusted for age at start of RRT and primary renal diseases, final height increased significantly over time from -2.06 SDS in children who reached adulthood in 1990-1995 to -1.33 SDS among those reaching adulthood in 2006-2011. Older age at start of RRT, more recent period of start of RRT, cumulative percentage time on a functioning graft, and greater height SDS at initiation of RRT were independently associated with a higher final height SDS. Patients with congenital anomalies of the kidney and urinary tract and metabolic disorders had a lower final height than those with other primary renal diseases.ConclusionsAlthough final height remains suboptimal in children with ESRD, it has consistently improved over time. (en)
Title
  • Adult Height in Patients with Advanced CKD Requiring Renal Replacement Therapy during Childhood
  • Adult Height in Patients with Advanced CKD Requiring Renal Replacement Therapy during Childhood (en)
skos:prefLabel
  • Adult Height in Patients with Advanced CKD Requiring Renal Replacement Therapy during Childhood
  • Adult Height in Patients with Advanced CKD Requiring Renal Replacement Therapy during Childhood (en)
skos:notation
  • RIV/00216208:11130/14:10293922!RIV15-MSM-11130___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 1716
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11130/14:10293922
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • weight; impairment; adolescents; failure; transplantation; young-children; final height; cross-sectional growth; chronic peritoneal-dialysis; chronic kidney-disease (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [336D44FEEE58]
http://linked.open...i/riv/nazevZdroje
  • Clinical Journal of the American Society of Nephrology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 9
http://linked.open...iv/tvurceVysledku
  • Vondrák, Karel
  • Seeman, Tomáš
  • Ariceta, Gema
  • Ivanov, D.
  • Topaloglu, R.
  • Schaefer, Franz
  • Jäger, Kitty J.
  • Verrina, Enrico
  • Battelino, Nina
  • Bjerre, Anna
  • Bonthuis, Marjolein
  • Combe, Christian
  • Duzova, A.
  • Feest, T.
  • Groothoff, Jaap W.
  • Harambat, Jerome
  • Hemke, A.
  • Hoitsma, A.
  • Invard, C.
  • Jahnukainen, Timo
  • Leroy, Valerie
  • Reusz, Gyoergy
  • Sandes, Ana R.
  • Sinha, Manish D.
  • Soylemezoglu, O.
  • van Stralen, Karlijn J.
http://linked.open...ain/vavai/riv/wos
  • 000329364700014
issn
  • 1555-9041
number of pages
http://bibframe.org/vocab/doi
  • 10.2215/CJN.00890113
http://localhost/t...ganizacniJednotka
  • 11130
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