About: Retinal toxicity after repeated intravitreal carboplatin injection into rabbit eyes

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.5507/bp.2012.106
Description	Background. The aim of this study was to assess retinal toxicity in a rabbit model after carboplatin delivered as repeated transcorneal intravitreal injection, in order to determine the highest possible safe dose for use in human retinoblastoma %22seeding%22 tumor chemotherapy. Methods and Results. We used six albino rabbits in an in vivo experiment and injected 0.008 mg of carboplatin intra-vitreally (iv) 4 times at two-week intervals. 0.08 mL saline was injected into the left eye. We recorded electroretinograms (ERGs) before the first carboplatin injection and after the fourth injection. Platinum concentration was measured 1 h after the fifth additional injection. We found reduced dark-adapted b-wave amplitudes and, light-adapted b-wave and a-wave amplitudes. The differences between right and left eyes was significant but we found no histopathologic retinal changes. Conclusions. 0.008 mg of carboplatin is probably the highest possible safe dose for the treatment of retinoblastoma patients. Questionable is direct extrapolation of retinal toxicity from the rabbit eye model to the human eye. Background. The aim of this study was to assess retinal toxicity in a rabbit model after carboplatin delivered as repeated transcorneal intravitreal injection, in order to determine the highest possible safe dose for use in human retinoblastoma %22seeding%22 tumor chemotherapy. Methods and Results. We used six albino rabbits in an in vivo experiment and injected 0.008 mg of carboplatin intra-vitreally (iv) 4 times at two-week intervals. 0.08 mL saline was injected into the left eye. We recorded electroretinograms (ERGs) before the first carboplatin injection and after the fourth injection. Platinum concentration was measured 1 h after the fifth additional injection. We found reduced dark-adapted b-wave amplitudes and, light-adapted b-wave and a-wave amplitudes. The differences between right and left eyes was significant but we found no histopathologic retinal changes. Conclusions. 0.008 mg of carboplatin is probably the highest possible safe dose for the treatment of retinoblastoma patients. Questionable is direct extrapolation of retinal toxicity from the rabbit eye model to the human eye. (en)
Title	Retinal toxicity after repeated intravitreal carboplatin injection into rabbit eyes Retinal toxicity after repeated intravitreal carboplatin injection into rabbit eyes (en)
skos:prefLabel	Retinal toxicity after repeated intravitreal carboplatin injection into rabbit eyes Retinal toxicity after repeated intravitreal carboplatin injection into rabbit eyes (en)
skos:notation	RIV/00216208:11130/14:10293070!RIV15-MSM-11130___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Klapková, Eva Kodetová, Daniela Pochop, Pavel Kukačka, Jiří Darsová, Denisa Uhlík, Jiří Vajner, Luděk Mališ, Josef
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	42555
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/14:10293070
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	retinoblastoma; rabbit; local treatment; intravitreal seeding; electroretinogram; carboplatin concentration (en)
http://linked.open.../riv/klicoveSlovo	intravitreal seeding retinoblastoma local treatment rabbit carboplatin concentration electroretinogram
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[8FC010D82822]
http://linked.open...i/riv/nazevZdroje	Biomedical Papers
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	158
http://linked.open...iv/tvurceVysledku	Klapková, Eva Darsová, Denisa Kodetová, Daniela Kukačka, Jiří Pochop, Pavel Uhlík, Jiří Vajner, Luděk Mališ, Josef Lestak, Jan
http://linked.open...ain/vavai/riv/wos	000347173200009
issn	1213-8118
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.5507/bp.2012.106
http://localhost/t...ganizacniJednotka	11130

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