About: Metallothionein polymorphisms in pathological processes

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1039/c3mt00132f
Description	Metallothioneins (MTs) are a class of metal-binding proteins characterized by a high cysteine content and low molecular weight. MTs play an important role in metal metabolism and protect cells against the toxic effects of radiation, alkylating agents and oxygen free radicals. The evidence that individual genetic characteristics of MTs play an important role in physiological and pathological processes associated with antioxidant defense and detoxification inspired targeted studies of genetic polymorphisms in a clinical context. In recent years, common MT polymorphisms were identified and associated with, particularly, western lifestyle diseases such as cancer, complications of atherosclerosis, and type 2 diabetes mellitus along with related complications. This review summarizes all evidence regarding MT polymorphisms of major human MTs (MT1, MT2, MT3 and MT4), their relation to pathological processes, and outlines specific applications of MTs as a set of genetic markers for certain pathologies. Metallothioneins (MTs) are a class of metal-binding proteins characterized by a high cysteine content and low molecular weight. MTs play an important role in metal metabolism and protect cells against the toxic effects of radiation, alkylating agents and oxygen free radicals. The evidence that individual genetic characteristics of MTs play an important role in physiological and pathological processes associated with antioxidant defense and detoxification inspired targeted studies of genetic polymorphisms in a clinical context. In recent years, common MT polymorphisms were identified and associated with, particularly, western lifestyle diseases such as cancer, complications of atherosclerosis, and type 2 diabetes mellitus along with related complications. This review summarizes all evidence regarding MT polymorphisms of major human MTs (MT1, MT2, MT3 and MT4), their relation to pathological processes, and outlines specific applications of MTs as a set of genetic markers for certain pathologies. (en)
Title	Metallothionein polymorphisms in pathological processes Metallothionein polymorphisms in pathological processes (en)
skos:prefLabel	Metallothionein polymorphisms in pathological processes Metallothionein polymorphisms in pathological processes (en)
skos:notation	RIV/00216208:11130/14:10292810!RIV15-MSM-11130___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Eckschlager, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	28568
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/14:10292810
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	transcription factor; mammalian metallothionein; iia gene; gene-expression; oxidative stress; central-nervous-system; prostate-specific antigen; amyotrophic-lateral-sclerosis; single-nucleotide polymorphisms; metal-responsive elements (en)
http://linked.open.../riv/klicoveSlovo	gene-expression single-nucleotide polymorphisms central-nervous-system oxidative stress amyotrophic-lateral-sclerosis transcription factor prostate-specific antigen iia gene mammalian metallothionein metal-responsive elements
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[581D8A986772]
http://linked.open...i/riv/nazevZdroje	Metallomics : integrated biometal science
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Babula, Petr Eckschlager, Tomáš Gumulec, Jaromír Masarik, Michal Raudenska, Martina Sztalmachova, Marketa Kizekb, Rene Podlaha, Ondrej
http://linked.open...ain/vavai/riv/wos	000328891100004
issn	1756-5901
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/c3mt00132f
http://localhost/t...ganizacniJednotka	11130

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