About: Juvenile generalized pustular psoriasis treated with etanercept     Goto   Sponge   NotDistinct   Permalink

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Description
  • An 8-year-old boy with general pustular psoriasis (GPP) and iatrogenic secondary Cushing syndrome was treated successfully with etanercept after he had failed on acitretin, methotrexate, and methylprednisolone therapy. GPP is a severe and very rare variant of psoriasis in children often accompanied by life-threatening complications. Retinoids, cyclosporine, methotrexate, or dapsone used in a small number of case series and case reports were effective. Etanercept is a recombinant human tumor necrosis factor-alpha (TNF-alpha) receptor protein fused with Fc portion of IgG1 that binds to TNF-alpha, approved by Food and Drug Administration for the treatment of moderate-to-severe plaque psoriasis in children and teens who have not responded to other psoriasis treatments. In our patient, etanercept demonstrated significant clinical response associated with long-term efficacy without acute exacerbation, excellent tolerability, and good safety profile.
  • An 8-year-old boy with general pustular psoriasis (GPP) and iatrogenic secondary Cushing syndrome was treated successfully with etanercept after he had failed on acitretin, methotrexate, and methylprednisolone therapy. GPP is a severe and very rare variant of psoriasis in children often accompanied by life-threatening complications. Retinoids, cyclosporine, methotrexate, or dapsone used in a small number of case series and case reports were effective. Etanercept is a recombinant human tumor necrosis factor-alpha (TNF-alpha) receptor protein fused with Fc portion of IgG1 that binds to TNF-alpha, approved by Food and Drug Administration for the treatment of moderate-to-severe plaque psoriasis in children and teens who have not responded to other psoriasis treatments. In our patient, etanercept demonstrated significant clinical response associated with long-term efficacy without acute exacerbation, excellent tolerability, and good safety profile. (en)
Title
  • Juvenile generalized pustular psoriasis treated with etanercept
  • Juvenile generalized pustular psoriasis treated with etanercept (en)
skos:prefLabel
  • Juvenile generalized pustular psoriasis treated with etanercept
  • Juvenile generalized pustular psoriasis treated with etanercept (en)
skos:notation
  • RIV/00216208:11130/14:10292749!RIV15-MSM-11130___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 23675
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11130/14:10292749
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • juvenile generalized pustular psoriasis; etanercept; childhood generalized pustular psoriasis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [0348D33F8F6C]
http://linked.open...i/riv/nazevZdroje
  • Dermatologic Therapy
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 27
http://linked.open...iv/tvurceVysledku
  • Hercogová, Jana
  • Vojáčková, Naděžda
  • Fialová, Jorga
  • Vaňousová, Daniela
http://linked.open...ain/vavai/riv/wos
  • 000333809400011
issn
  • 1396-0296
number of pages
http://bibframe.org/vocab/doi
  • 10.1111/dth.12065
http://localhost/t...ganizacniJednotka
  • 11130
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