About: Ontogenetic Aspects of Cardiac Adaptation to Chronic Hypoxia

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Ontogenetic Aspects of Cardiac Adaptation to Chronic Hypoxia Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://link.springer.com/chapter/10.1007/978-1-4614-5203-4_6
Description	One of the most common insults during early stages of postnatal ontogenetic development is hypoxemia due to cyanotic congenital heart defects. The question of the presumed cardiac impact will be, therefore, of considerable importance. Experimental results have clearly shown that the immature heart is significantly more tolerant to acute oxygen deficiency than the adult myocardium. However, the mechanisms of this difference have not yet been satisfactorily clarified; they are likely the result of developmental changes in cardiac mitochondrial function and energy metabolism. Adaptation to chronic hypoxia confers long-lasting protection in both adult and immature heart. However, the already high resistance of the newborn heart cannot be further increased; the effects of protective mechanisms appear only when the ischemic tolerance starts to decrease during development. Early chronic hypoxia, although transient, may have serious sex-dependent late consequences on the adult cardiovascular system. These results support the view that precise knowledge of individual developmental periods that are critical for cardiac ontogeny is crucial for better understanding of the mechanism of cardiac adaptation to oxygen deficiency. One of the most common insults during early stages of postnatal ontogenetic development is hypoxemia due to cyanotic congenital heart defects. The question of the presumed cardiac impact will be, therefore, of considerable importance. Experimental results have clearly shown that the immature heart is significantly more tolerant to acute oxygen deficiency than the adult myocardium. However, the mechanisms of this difference have not yet been satisfactorily clarified; they are likely the result of developmental changes in cardiac mitochondrial function and energy metabolism. Adaptation to chronic hypoxia confers long-lasting protection in both adult and immature heart. However, the already high resistance of the newborn heart cannot be further increased; the effects of protective mechanisms appear only when the ischemic tolerance starts to decrease during development. Early chronic hypoxia, although transient, may have serious sex-dependent late consequences on the adult cardiovascular system. These results support the view that precise knowledge of individual developmental periods that are critical for cardiac ontogeny is crucial for better understanding of the mechanism of cardiac adaptation to oxygen deficiency. (en)
Title	Ontogenetic Aspects of Cardiac Adaptation to Chronic Hypoxia Ontogenetic Aspects of Cardiac Adaptation to Chronic Hypoxia (en)
skos:prefLabel	Ontogenetic Aspects of Cardiac Adaptation to Chronic Hypoxia Ontogenetic Aspects of Cardiac Adaptation to Chronic Hypoxia (en)
skos:notation	RIV/00216208:11130/13:10210371!RIV14-MSM-11130___
http://linked.open...avai/predkladatel	2. lékařská fakulta
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GAP303/12/1162), Z(AV0Z50110509)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Charvátová, Zuzana Ošťádal, Bohuslav
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	94070
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/13:10210371
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cardiac Adaptation; Chronic Hypoxia (en)
http://linked.open.../riv/klicoveSlovo	Cardiac Adaptation Chronic Hypoxia
http://linked.open...ontrolniKodProRIV	[F573992280CA]
http://linked.open...i/riv/mistoVydani	USA
http://linked.open...vEdiceCisloSvazku	Advances in Biochemistry in Health and Disease, 4
http://linked.open...i/riv/nazevZdroje	Cardiac Adaptations
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...v/pocetStranKnihy	402 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Interaction between sustained forms of cardioprotection induced by adaptation to chronic hypoxia and regular exercise training.
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Kolář, František Ošťádalová, Ivana Ošťádal, Bohuslav Charvátová, Zuzana
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/978-1-4614-5203-4_6
http://purl.org/ne...btex#hasPublisher	Springer Science+Bussines
https://schema.org/isbn	978-1-4614-5202-7
http://localhost/t...ganizacniJednotka	11130

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 112 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software