About: Flt3 ligand expands CD4+FoxP3+regulatory T cells in human subjects

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About: Flt3 ligand expands CD4+FoxP3+regulatory T cells in human subjects Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1002/eji.201242603
Description	CD4+CD25+FoxP3+ naturally occurring regulatory T (Treg) cells play a crucial role in the maintenance of immune tolerance and in preventing autoimmune pathology. Interventions that expand Treg cells are highly desirable, as they may offer novel treatment options in a variety of autoimmune and transplantation settings. Paralleling previous preclinical studies, we demonstrate here that administration of the hematopoietic growth factor Flt3L to human subjects increases the frequency and absolute number of Treg cells, and reduces the ratio of CD8+ T cells to Treg cells in the peripheral blood. The increase in Treg cells was due to enhanced Treg-cell proliferation rather than release of Treg cells from the thymus. Further studies revealed that Flt3L-induced proliferation of Treg cells was an indirect effect that occurred via the interaction of Treg cells with the Flt3L-expanded pool of CD1c+ myeloid dendritic cells. On the basis of these findings, Flt3L may represent a promising agent for promoting immune tolerance in a variety of clinical settings. CD4+CD25+FoxP3+ naturally occurring regulatory T (Treg) cells play a crucial role in the maintenance of immune tolerance and in preventing autoimmune pathology. Interventions that expand Treg cells are highly desirable, as they may offer novel treatment options in a variety of autoimmune and transplantation settings. Paralleling previous preclinical studies, we demonstrate here that administration of the hematopoietic growth factor Flt3L to human subjects increases the frequency and absolute number of Treg cells, and reduces the ratio of CD8+ T cells to Treg cells in the peripheral blood. The increase in Treg cells was due to enhanced Treg-cell proliferation rather than release of Treg cells from the thymus. Further studies revealed that Flt3L-induced proliferation of Treg cells was an indirect effect that occurred via the interaction of Treg cells with the Flt3L-expanded pool of CD1c+ myeloid dendritic cells. On the basis of these findings, Flt3L may represent a promising agent for promoting immune tolerance in a variety of clinical settings. (en)
Title	Flt3 ligand expands CD4+FoxP3+regulatory T cells in human subjects Flt3 ligand expands CD4+FoxP3+regulatory T cells in human subjects (en)
skos:prefLabel	Flt3 ligand expands CD4+FoxP3+regulatory T cells in human subjects Flt3 ligand expands CD4+FoxP3+regulatory T cells in human subjects (en)
skos:notation	RIV/00216208:11130/13:10209661!RIV14-MSM-11130___
http://linked.open...avai/predkladatel	2. lékařská fakulta
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Fučíková, Jitka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	75335
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/13:10209661
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Regulatory T (Treg) cells; Immune tolerance; Flt3 ligand (en)
http://linked.open.../riv/klicoveSlovo	Flt3 ligand Immune tolerance Regulatory T (Treg) cells
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9CC73D46CFA3]
http://linked.open...i/riv/nazevZdroje	European Journal of Immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	43
http://linked.open...iv/tvurceVysledku	Fučíková, Jitka Behren, Andreas Cebon, Jonathan Chen, Weisan Davis, Ian D. Ebert, Lisa M. Klein, Oliver Maraskovsky, Eugene Tan, Bee Shin Woods, Katherine Zanker, Damien
http://linked.open...ain/vavai/riv/wos	000315051100026
issn	0014-2980
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/eji.201242603
http://localhost/t...ganizacniJednotka	11130

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