About: Time-regulated drug delivery system based on coaxially incorporated platelet alpha-granules for biomedical use

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About: Time-regulated drug delivery system based on coaxially incorporated platelet alpha-granules for biomedical use Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.2217/NNM.12.140
Description	Platelet derivatives serve as an efficient source of natural growth factors. In the current study, alpha-granules were incorporated into coaxial nanofibers. Materials & methods: A nanofiber scaffold containing a-granules was prepared by coaxial electrospinning. The biological potential of the nanofiber scaffold was evaluated in chondrocyte and mesenchymal stem cell cultivation studies. Additionally, the concentration of TGF-beta 1 was determined. Results: Microscopy studies showed that intact alpha-granules were incorporated into the coaxial nanofibers. The cultivation tests showed that the novel scaffold stimulated viability and extracellular matrix production of chondrocytes and mesenchymal stem cells. In addition, the concentration of growth factors necessary for the induction of cell proliferation significantly decreased. Conclusion: The system preserved alpha-granule bioactivity and stimulated cell viability and chondrogenic differentiation of mesenchymal stem cells. Core/shell nanofibers incorporating a-granules are a promising system for tissue engineering, particularly cartilage engineering. Platelet derivatives serve as an efficient source of natural growth factors. In the current study, alpha-granules were incorporated into coaxial nanofibers. Materials & methods: A nanofiber scaffold containing a-granules was prepared by coaxial electrospinning. The biological potential of the nanofiber scaffold was evaluated in chondrocyte and mesenchymal stem cell cultivation studies. Additionally, the concentration of TGF-beta 1 was determined. Results: Microscopy studies showed that intact alpha-granules were incorporated into the coaxial nanofibers. The cultivation tests showed that the novel scaffold stimulated viability and extracellular matrix production of chondrocytes and mesenchymal stem cells. In addition, the concentration of growth factors necessary for the induction of cell proliferation significantly decreased. Conclusion: The system preserved alpha-granule bioactivity and stimulated cell viability and chondrogenic differentiation of mesenchymal stem cells. Core/shell nanofibers incorporating a-granules are a promising system for tissue engineering, particularly cartilage engineering. (en)
Title	Time-regulated drug delivery system based on coaxially incorporated platelet alpha-granules for biomedical use Time-regulated drug delivery system based on coaxially incorporated platelet alpha-granules for biomedical use (en)
skos:prefLabel	Time-regulated drug delivery system based on coaxially incorporated platelet alpha-granules for biomedical use Time-regulated drug delivery system based on coaxially incorporated platelet alpha-granules for biomedical use (en)
skos:notation	RIV/00216208:11130/13:10209656!RIV14-MSM-11130___
http://linked.open...avai/predkladatel	2. lékařská fakulta
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GAP304/10/1307), P(ME10145), S, Z(AV0Z50390512), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Jakubová, Radka Buzgo, Matej Míčková, Andrea Rampichová, Michala Prosecká, Eva Amler, Evžen
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	111118
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/13:10209656
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mesenchymal stem cell; growth factor; encapsulation; electrospinning; core/shell material; chondrocyte; alpha-granules (en)
http://linked.open.../riv/klicoveSlovo	growth factor chondrocyte electrospinning alpha-granules core/shell material mesenchymal stem cell encapsulation
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[F0B22F6415C1]
http://linked.open...i/riv/nazevZdroje	Nanomedicine
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Modification of nanofibers materials by plasma technologies for biomedical applications Smart nanofiber/liposme composite scaffold for bone regeneration
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Amler, Evžen Jakubová, Radka Míčková, Andrea Prosecká, Eva Rampichová, Michala Buzgo, Matej Kochova, Petra Lukas, David
http://linked.open...ain/vavai/riv/wos	000320853500017
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	1743-5889
number of pages	18 (xsd:int)
http://bibframe.org/vocab/doi	10.2217/NNM.12.140
http://localhost/t...ganizacniJednotka	11130

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