About: Quiescent leukaemic cells account for minimal residual disease in childhood lymphoblastic leukaemia     Goto   Sponge   NotDistinct   Permalink

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Description
  • Relapses after therapy-induced remissions remain a major challenge in cancer. Molecular detection of minimal residual disease (MRD) is valuable in relapse prediction but its cellular basis remains largely unknown. Delineating therapy-resistant cells might inform new therapeutic strategies. 'Cancer stem cells', defined by xenografting, have been suggested to preferentially evade therapy, but evidence for persistence of phenotypically and functionally distinct cells in patients undergoing treatment is largely lacking.
  • Relapses after therapy-induced remissions remain a major challenge in cancer. Molecular detection of minimal residual disease (MRD) is valuable in relapse prediction but its cellular basis remains largely unknown. Delineating therapy-resistant cells might inform new therapeutic strategies. 'Cancer stem cells', defined by xenografting, have been suggested to preferentially evade therapy, but evidence for persistence of phenotypically and functionally distinct cells in patients undergoing treatment is largely lacking. (en)
Title
  • Quiescent leukaemic cells account for minimal residual disease in childhood lymphoblastic leukaemia
  • Quiescent leukaemic cells account for minimal residual disease in childhood lymphoblastic leukaemia (en)
skos:prefLabel
  • Quiescent leukaemic cells account for minimal residual disease in childhood lymphoblastic leukaemia
  • Quiescent leukaemic cells account for minimal residual disease in childhood lymphoblastic leukaemia (en)
skos:notation
  • RIV/00216208:11130/13:10209587!RIV14-MZ0-11130___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(NT12428)
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 101277
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11130/13:10209587
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • trials; children; aieop-bfm; stem-cells (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [FC68C8C61B00]
http://linked.open...i/riv/nazevZdroje
  • Leukemia
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 27
http://linked.open...iv/tvurceVysledku
  • Zuna, Jan
  • Biondi, A.
  • Castor, A.
  • Cazzaniga, G.
  • Buckle, V.
  • Clark, S. A.
  • Dreau, H.
  • Enver, T.
  • Ferry, H.
  • Hall, G.
  • Jacobsen, S-E W.
  • Jensen, C.
  • Lutz, C.
  • Mitchell, C.
  • Schuh, A.
  • Woll, P. S.
http://linked.open...ain/vavai/riv/wos
  • 000318698300032
issn
  • 0887-6924
number of pages
http://bibframe.org/vocab/doi
  • 10.1038/leu.2012.306
http://localhost/t...ganizacniJednotka
  • 11130
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