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Description
  • Vitiligo is a depigmenting disorder stemming from melanocyte loss or dysfunction. It has a complex, multifaceted etiology. We constructed a vitiligo road map, consisting of basic science, clinical, and treatment components, in order to better portray our current understanding of vitiligo pathogenesis and reflect upon novel biomarkers and therapeutic targets for future research. The melanocyte map elaborates on the molecular processes and intracellular signaling pathways initiated by various external autocrine/paracrine factors in representing normal melanocyte homeostatic functions modulating its viability, proliferation, differentiation, dendricity, migration, and melanogenic processes. This vitiligo map identifies known inducers/triggers of vitiligo onset and progression that cultivate a microenvironment for melanocyte disappearance, real or functional. This map describes the molecular mechanisms of currently utilized clinical and experimental treatments of vitiligo that facilitate repigmentation.
  • Vitiligo is a depigmenting disorder stemming from melanocyte loss or dysfunction. It has a complex, multifaceted etiology. We constructed a vitiligo road map, consisting of basic science, clinical, and treatment components, in order to better portray our current understanding of vitiligo pathogenesis and reflect upon novel biomarkers and therapeutic targets for future research. The melanocyte map elaborates on the molecular processes and intracellular signaling pathways initiated by various external autocrine/paracrine factors in representing normal melanocyte homeostatic functions modulating its viability, proliferation, differentiation, dendricity, migration, and melanogenic processes. This vitiligo map identifies known inducers/triggers of vitiligo onset and progression that cultivate a microenvironment for melanocyte disappearance, real or functional. This map describes the molecular mechanisms of currently utilized clinical and experimental treatments of vitiligo that facilitate repigmentation. (en)
Title
  • Vitiligo road map
  • Vitiligo road map (en)
skos:prefLabel
  • Vitiligo road map
  • Vitiligo road map (en)
skos:notation
  • RIV/00216208:11130/12:8273!RIV13-MSM-11130___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 177621
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11130/12:8273
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • biomarkers; vitiligo; melanocyte; pigmentation; melanogenesis; hepatocyte growth-factor; melanocyte-stimulating hormone; non-segmental vitiligo; narrow-band-uvb; extracellular-matrix components; psoralen plus ultraviolet; factor scatter factor; c-kit ligand; nitric-oxide; t-cells (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [C20A77EBA27F]
http://linked.open...i/riv/nazevZdroje
  • Dermatologic Therapy
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 25
http://linked.open...iv/tvurceVysledku
  • Hercogová, Jana
  • Lotti, T. M.
  • Schwartz, R. A.
  • Valle, Y.
  • Lee, BW
http://linked.open...ain/vavai/riv/wos
  • 000312304200007
issn
  • 1396-0296
number of pages
http://localhost/t...ganizacniJednotka
  • 11130
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