About: Evaluation of toxicity after periocular and intravitreal administration of carboplatin in rabbit eyes

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About: Evaluation of toxicity after periocular and intravitreal administration of carboplatin in rabbit eyes Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://actavet.vfu.cz/pdf/201180040385.pdf
Description	The aim of this study was to characterize the extent of toxicity of focal carboplatin administration and to identify the dose limiting toxicity in rabbit eyes depending on administered concentrations.The dose limiting toxicity was reached in group II after periocular injection of 30 mg of carboplatin and in group III after intravitreal injection of 0.05 mg of carboplatin. No systemic toxicity was observed in any group.Focal carboplatin administration may decrease systemic exposure to this cytotoxic drug in the retinoblastoma treatment. This moreover suggests that focal carboplatin administration is a promising approach and challenge for advanced retinoblastoma chemotherapy. The aim of this study was to characterize the extent of toxicity of focal carboplatin administration and to identify the dose limiting toxicity in rabbit eyes depending on administered concentrations.The dose limiting toxicity was reached in group II after periocular injection of 30 mg of carboplatin and in group III after intravitreal injection of 0.05 mg of carboplatin. No systemic toxicity was observed in any group.Focal carboplatin administration may decrease systemic exposure to this cytotoxic drug in the retinoblastoma treatment. This moreover suggests that focal carboplatin administration is a promising approach and challenge for advanced retinoblastoma chemotherapy. (en)
Title	Evaluation of toxicity after periocular and intravitreal administration of carboplatin in rabbit eyes Evaluation of toxicity after periocular and intravitreal administration of carboplatin in rabbit eyes (en)
skos:prefLabel	Evaluation of toxicity after periocular and intravitreal administration of carboplatin in rabbit eyes Evaluation of toxicity after periocular and intravitreal administration of carboplatin in rabbit eyes (en)
skos:notation	RIV/00216208:11130/11:7571!RIV12-MZ0-11130___
http://linked.open...avai/predkladatel	2. lékařská fakulta
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NR9532)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kodetová, Daniela Pochop, Pavel Kukačka, Jiří Darsová, Denisa Dotřelová, Dagmar Uhlík, Jiří Vajner, Luděk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	198407
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/11:7571
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	carboplatin chemotherapy; New Zealand White Rabbits; intravitreal treatment; periocular toxicity; retinoblastoma (en)
http://linked.open.../riv/klicoveSlovo	New Zealand White Rabbits carboplatin chemotherapy intravitreal treatment periocular toxicity retinoblastoma
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[1B5603271B63]
http://linked.open...i/riv/nazevZdroje	Acta Veterinaria Brno
http://linked.open...in/vavai/riv/obor	FF
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Measurement of the concentration of cytostatics in the vitreous cavity of rabbits eye ball after trancorneal and subconjunctival administration
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	80
http://linked.open...iv/tvurceVysledku	Darsová, Denisa Dotřelová, Dagmar Kodetová, Daniela Kukačka, Jiří Pochop, Pavel Uhlík, Jiří Vajner, Luděk
http://linked.open...ain/vavai/riv/wos	000301811400011
issn	0001-7213
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	11130
is http://linked.open...avai/riv/vysledek of	Evaluation of toxicity after periocular and intravitreal administration of carboplatin in rabbit eyes Evaluation of toxicity after periocular and intravitreal administration of carboplatin in rabbit eyes

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