About: Intravitreal carboplatin concentration and area under concentration versus time curve after intravitreal and periocular delivery     Goto   Sponge   NotDistinct   Permalink

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  • PURPOSE. To determine platinum (Pt) concentrations and area under the concentration versus time curve (AUC) of the vitreous humor after periocular or transcorneal intravitreal administration of carboplatin in rabbits. METHODS. Eighteen albino rabbits were included in an in vivo experiment. Each animal received a single dose of either 30 mg of carboplatin by periocular injection (POI30 group: n=6) or 15 mg by periocular injection (POI15 group: n=6), or 0.05 mg by transcorneal intravitreal injection (TII group: n=6), respectively, into the right eye. RESULTS. Pt concentration was mostly <1 mg/L (0-3.15 mg/L) in the vitreous humor samples and >= 2 mg/L (2.33-7.3 mg/L) in the blood samples 1 hour after administration in POI groups. Markedly higher Pt concentrations were found 1 hour after intravitreal (Ill) administration (10.285-66.759 mg/L) and decreased below 1 mg/L no less than 168 hours after administration.
  • PURPOSE. To determine platinum (Pt) concentrations and area under the concentration versus time curve (AUC) of the vitreous humor after periocular or transcorneal intravitreal administration of carboplatin in rabbits. METHODS. Eighteen albino rabbits were included in an in vivo experiment. Each animal received a single dose of either 30 mg of carboplatin by periocular injection (POI30 group: n=6) or 15 mg by periocular injection (POI15 group: n=6), or 0.05 mg by transcorneal intravitreal injection (TII group: n=6), respectively, into the right eye. RESULTS. Pt concentration was mostly <1 mg/L (0-3.15 mg/L) in the vitreous humor samples and >= 2 mg/L (2.33-7.3 mg/L) in the blood samples 1 hour after administration in POI groups. Markedly higher Pt concentrations were found 1 hour after intravitreal (Ill) administration (10.285-66.759 mg/L) and decreased below 1 mg/L no less than 168 hours after administration. (en)
Title
  • Intravitreal carboplatin concentration and area under concentration versus time curve after intravitreal and periocular delivery
  • Intravitreal carboplatin concentration and area under concentration versus time curve after intravitreal and periocular delivery (en)
skos:prefLabel
  • Intravitreal carboplatin concentration and area under concentration versus time curve after intravitreal and periocular delivery
  • Intravitreal carboplatin concentration and area under concentration versus time curve after intravitreal and periocular delivery (en)
skos:notation
  • RIV/00216208:11130/10:6375!RIV11-MZ0-11130___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(NR9532)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 264717
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  • RIV/00216208:11130/10:6375
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  • AUC; Carboplatin concentration; Local treatment; Intravitreal seeding; Periocular injection; Rabbit; Retinoblastoma; Transcorneal; transgenic murine retinoblastoma; subconjunctival carboplatin; intraocular retinoblastoma; chemotherapy; pharmacokinetics; cryotherapy; therapy; eye (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • IT - Italská republika
http://linked.open...ontrolniKodProRIV
  • [C856DADE555F]
http://linked.open...i/riv/nazevZdroje
  • European Journal of Ophthalmology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 20
http://linked.open...iv/tvurceVysledku
  • Tesfaye, Hundie
  • Darsová, Denisa
  • Dotřelová, Dagmar
  • Kodetová, Daniela
  • Kukačka, Jiří
  • Pochop, Pavel
  • Uhlík, Jiří
  • Vajner, Luděk
  • Mališ, Josef
http://linked.open...ain/vavai/riv/wos
  • 000280191600016
issn
  • 1120-6721
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  • 11130
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