About: Distinct effects of sonic hedgehog and wnt-7a on differentiation of neonatal neural stem/progenitor cells in vitro

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We explored the effect of two morphogens Sonic hedgehog (Shh) and Wnt-7a on the proliferation, differentiation and membrane properties of neonatal neural stem/progenitor cells (NS/PCs) transduced with either Shh- or Wnt-7a. We found that Shh and Wnt-7a interfere differently with the process of neuronal differentiation and that they promote electrophysiologically and immunohistochemically distinct stages of neuronal differentiation in neonatal NS/PCs. We explored the effect of two morphogens Sonic hedgehog (Shh) and Wnt-7a on the proliferation, differentiation and membrane properties of neonatal neural stem/progenitor cells (NS/PCs) transduced with either Shh- or Wnt-7a. We found that Shh and Wnt-7a interfere differently with the process of neuronal differentiation and that they promote electrophysiologically and immunohistochemically distinct stages of neuronal differentiation in neonatal NS/PCs. (en)
Title	Distinct effects of sonic hedgehog and wnt-7a on differentiation of neonatal neural stem/progenitor cells in vitro Distinct effects of sonic hedgehog and wnt-7a on differentiation of neonatal neural stem/progenitor cells in vitro (en)
skos:prefLabel	Distinct effects of sonic hedgehog and wnt-7a on differentiation of neonatal neural stem/progenitor cells in vitro Distinct effects of sonic hedgehog and wnt-7a on differentiation of neonatal neural stem/progenitor cells in vitro (en)
skos:notation	RIV/00216208:11130/10:6360!RIV11-GA0-11130___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(1M0538), P(GA305/09/0717), P(GD309/08/H079), P(LC554), S, Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Prajerová, Iva Anděrová, Miroslava Chvátal, Alexandr Honsa, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	254688
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/10:6360
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	morphogen; potassium currents; sodium currents; membrane properties; patch-clamp; neurogenesis; postnatal subventricular zone; wnt/beta-catenin pathway; central-nervous-system; stem-cells; progenitor cells; adult brain; hippocampal neurogenesis; precursor cells; neuronal differentiation; functional-neurons (en)
http://linked.open.../riv/klicoveSlovo	neuronal differentiation central-nervous-system membrane properties progenitor cells neurogenesis stem-cells adult brain functional-neurons hippocampal neurogenesis morphogen patch-clamp postnatal subventricular zone potassium currents precursor cells sodium currents wnt/beta-catenin pathway
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[BDD658BFEF71]
http://linked.open...i/riv/nazevZdroje	Neuroscience
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	PhD program in neuroscience Center for Cell Therapy and Tissue Repair Neuroscience Centre Induction of neuro- and gliogenesis in rat brain after ischemia - the role of morphogenes and growth factors in the nervous tissue regeneration.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	171
http://linked.open...iv/tvurceVysledku	Anděrová, Miroslava Chvátal, Alexandr Honsa, Pavel Prajerová, Iva
http://linked.open...ain/vavai/riv/wos	000284733700006
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0306-4522
number of pages	19 (xsd:int)
http://localhost/t...ganizacniJednotka	11130
is http://linked.open...avai/riv/vysledek of	Distinct effects of sonic hedgehog and wnt-7a on differentiation of neonatal neural stem/progenitor cells in vitro Distinct effects of sonic hedgehog and wnt-7a on differentiation of neonatal neural stem/progenitor cells in vitro Distinct effects of sonic hedgehog and wnt-7a on differentiation of neonatal neural stem/progenitor cells in vitro

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