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| rdf:type
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| Description
| - The authors address the issues of drug design and specificity and focus the discussion on recent findings on oxytocin and its heterotrimeric G protein-coupled receptor OTR in the following topics: (i) the role of oxytocin in behavior and affectivity, (ii) the relationship between oxytocin and stress with emphasis on the hypothalamo-pituitary-adrenal axis, (iii) the involvement of oxytocin in pain regulation and nociception, (iv) the specific action mechanisms of oxytocin on intracellular Ca2+ in the hypothalamo neurohypophysial system (HNS) cell bodies, (v) newly generated transgenic rats tagged by a visible fluorescent protein to study the physiology of vasopressin and oxytocin, and (vi) the action of the neurohypophysial hormone outside the central nervous system, including the myometrium, heart and peripheral nervous system. Understanding the fundamental physiopharmacology of the effects of oxytocin is an important and necessary approach for developing a potential pharmacotherapy.
- The authors address the issues of drug design and specificity and focus the discussion on recent findings on oxytocin and its heterotrimeric G protein-coupled receptor OTR in the following topics: (i) the role of oxytocin in behavior and affectivity, (ii) the relationship between oxytocin and stress with emphasis on the hypothalamo-pituitary-adrenal axis, (iii) the involvement of oxytocin in pain regulation and nociception, (iv) the specific action mechanisms of oxytocin on intracellular Ca2+ in the hypothalamo neurohypophysial system (HNS) cell bodies, (v) newly generated transgenic rats tagged by a visible fluorescent protein to study the physiology of vasopressin and oxytocin, and (vi) the action of the neurohypophysial hormone outside the central nervous system, including the myometrium, heart and peripheral nervous system. Understanding the fundamental physiopharmacology of the effects of oxytocin is an important and necessary approach for developing a potential pharmacotherapy. (en)
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| Title
| - Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy
- Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy (en)
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| skos:prefLabel
| - Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy
- Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy (en)
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| skos:notation
| - RIV/00216208:11130/10:6286!RIV11-GA0-11130___
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| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(1M0538), P(GA305/08/1384), P(GA309/08/1381), P(GA309/09/1597), P(LC554), Z(AV0Z50390512)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11130/10:6286
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - ACTH; Analgesics; Behavior; c-fos-mRFP1 fusion gene; CNS; Development; Drug design; eGFP; eCFP; Glial cells; Heart; HPA; Hypothalamus; Neurohypophysis; Neuropeptides; PNS; Receptors; Stress; Transgenic rat model; Vasopressin; green fluorescent protein; rat supraoptic nucleus; stimulated adrenocorticotropin release; hypothalamic-neurohypophyseal system; intracellular transduction signals; caveolin-1 enriched domains; randomized controlled-trial; vasopressin v-1a receptors; spinal-cord synaptosomes; anterior-pituitary-cells (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - CNS Neuroscience & Therapeutics
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Syková, Eva
- Fujihara, H.
- Ueta, Y.
- Kitamura, N.
- Chvátal, Alexandr
- Verkhratsky, A.
- Shibuya, I.
- Viero, C.
- Dayanithi, G.
- Katoh, A.
- Zingg, H. H.
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| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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