About: Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Burkholderia cepacia complex (Bcc) bacteria have gained notoriety as pathogens in cystic fibrosis (CF) because they are difficult to identify and treat and have the ability to spread between CF individuals. Of the 17 formally named species within the complex, Burkholderia cenocepacia dominate in CF, with highly transmissible strains such as the ET-12 (ST-28) and Czech strain (ST-32). The majority of research on the molecular pathogenesis of Bcc bacteria has focused on B. cenocepacia ET-12 epidemic lineage, with gene mutation, genome sequence analysis and most recently global gene expression studies shedding considerable light on the virulence and antimicrobial resistance of this pathogen. These studies demonstrate that the ability of B. cenocepacia to acquire foreign DNA, regulate gene expression, compete for iron during infection, and mediate antimicrobial resistance via its polysaccharides, are key features that underpin the virulence of different strains. Burkholderia cepacia complex (Bcc) bacteria have gained notoriety as pathogens in cystic fibrosis (CF) because they are difficult to identify and treat and have the ability to spread between CF individuals. Of the 17 formally named species within the complex, Burkholderia cenocepacia dominate in CF, with highly transmissible strains such as the ET-12 (ST-28) and Czech strain (ST-32). The majority of research on the molecular pathogenesis of Bcc bacteria has focused on B. cenocepacia ET-12 epidemic lineage, with gene mutation, genome sequence analysis and most recently global gene expression studies shedding considerable light on the virulence and antimicrobial resistance of this pathogen. These studies demonstrate that the ability of B. cenocepacia to acquire foreign DNA, regulate gene expression, compete for iron during infection, and mediate antimicrobial resistance via its polysaccharides, are key features that underpin the virulence of different strains. (en)
Title	Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence (en)
skos:prefLabel	Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence (en)
skos:notation	RIV/00216208:11130/10:6241!RIV11-MZ0-11130___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NS10543), Z(MSM0021620812)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Dřevínek, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	249384
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/10:6241
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Burkholderia cepacia; epidemiology; genomics; review; multilocus sequence typing; virulence factors; quorum-sensing system; cepacia-complex; genomovar III; ornibactin biosynthesis; global epidemiology; oxidative stress (en)
http://linked.open.../riv/klicoveSlovo	virulence factors epidemiology review multilocus sequence typing oxidative stress Burkholderia cepacia cepacia-complex genomovar III global epidemiology ornibactin biosynthesis quorum-sensing system genomics
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D5DEDB8B5F5A]
http://linked.open...i/riv/nazevZdroje	Clinical Microbiology and Infection
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular identification of bacterial strains which cause severe epidemics in Czech patients with cystic fibrosis and prevention of their spread within this population
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Dřevínek, Pavel Mahenthiralingam, E.
http://linked.open...ain/vavai/riv/wos	000278645700004
http://linked.open...n/vavai/riv/zamer	Chronická onemocnění vznikající na podkladě nepřiměřené reaktivity imunitního systému, jejich patogeneze a možnosti včasné diagnostiky a léčby
issn	1198-743X
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	11130
is http://linked.open...avai/riv/vysledek of	Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence

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