About: Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat

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About: Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Olfactory ensheathing glia (OEG) and mesenchymal stromal cells (MSC) have been investigated as promising candidates for spinal cord repair. In this study, the effect of the transplantation of OEG and/or MSC on behavioral, electrophysiologic and histologic outcomes after SCI was studied. Both OEG and MSC could foster locomotor function by sparing the spinal cord, but their combined advantages provide no added benefit to SCI therapy. We speculate that to maximize the advantageous effects of co-transplantation, direct implantation of OEG into the spinal cord lesion accompanied by intravenous injection of MSC might be more efficacious approach to the co-transplantation of OEG and MSC. Olfactory ensheathing glia (OEG) and mesenchymal stromal cells (MSC) have been investigated as promising candidates for spinal cord repair. In this study, the effect of the transplantation of OEG and/or MSC on behavioral, electrophysiologic and histologic outcomes after SCI was studied. Both OEG and MSC could foster locomotor function by sparing the spinal cord, but their combined advantages provide no added benefit to SCI therapy. We speculate that to maximize the advantageous effects of co-transplantation, direct implantation of OEG into the spinal cord lesion accompanied by intravenous injection of MSC might be more efficacious approach to the co-transplantation of OEG and MSC. (en)
Title	Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat (en)
skos:prefLabel	Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat (en)
skos:notation	RIV/00216208:11130/10:6058!RIV11-GA0-11130___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1A8697), P(1M0538), P(GA309/06/1246), P(IAA500390902), P(LC554), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Syková, Eva Jendelová, Pavla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	252241
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/10:6058
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	stem-cells; schwann-cells; in-vivo; cavity formation; lamina-propria; white-matter; migration; recovery; rho; regeneration (en)
http://linked.open.../riv/klicoveSlovo	recovery migration in-vivo white-matter regeneration stem-cells cavity formation lamina-propria rho schwann-cells
http://linked.open...odStatuVydavatele	NO - Norské království
http://linked.open...ontrolniKodProRIV	[623CFC2252AB]
http://linked.open...i/riv/nazevZdroje	Cytotherapy
http://linked.open...in/vavai/riv/obor	FJ
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	The utilization of biocompatible macroporous hydrogels containing cell cultures in the therapy of spinal cord injuries The use of stem cells and biomaterials for spinal cord injury repair Center for Cell Therapy and Tissue Repair Neuroscience Centre Utilization of olfactory ensheathing glia and bone marrow stromal cells for spinal cord injury repair
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Syková, Eva Jendelová, Pavla Amemori, T. Arboleda, D. Ruzickova, K.
http://linked.open...ain/vavai/riv/wos	000275110600010
http://linked.open...n/vavai/riv/zamer	New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	1465-3249
number of pages	14 (xsd:int)
http://localhost/t...ganizacniJednotka	11130
is http://linked.open...avai/riv/vysledek of	Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat

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