About: Valproic Acid in the Complex Therapy of Malignant Tumors

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Valproic acid (VPA) has been used for epilepsy treatment since the 1970s. Recently, it was demonstrated that it inhibits histone deacetylases (HDAC), modulates cell cycle, induces tumor cell death and inhibits angiogenesis. The exact anticancer mechanisms of VPA remains unclear, but HDAC inhibition, extracellular-regulated kinase activation, protein kinase C inhibition, Wnt-signaling activation, proteasomal degradation of HDAC, downregulation of telomerase activity and DNA demethylation participate in its anticancer effect. Hyperacetylation of histones, as a result of HDAC inhibition, seems to be the most important mechanism of VPA's antitumor action. Preclinical data suggest that the anticancer effect of chemotherapy is augmented when VPA is used in combination with cytostatics. We have demonstrated the synergistic effects of VPA and cisplatin in neuroblastoma. Clinical trials in patients with malignancies are being conducted. Valproic acid (VPA) has been used for epilepsy treatment since the 1970s. Recently, it was demonstrated that it inhibits histone deacetylases (HDAC), modulates cell cycle, induces tumor cell death and inhibits angiogenesis. The exact anticancer mechanisms of VPA remains unclear, but HDAC inhibition, extracellular-regulated kinase activation, protein kinase C inhibition, Wnt-signaling activation, proteasomal degradation of HDAC, downregulation of telomerase activity and DNA demethylation participate in its anticancer effect. Hyperacetylation of histones, as a result of HDAC inhibition, seems to be the most important mechanism of VPA's antitumor action. Preclinical data suggest that the anticancer effect of chemotherapy is augmented when VPA is used in combination with cytostatics. We have demonstrated the synergistic effects of VPA and cisplatin in neuroblastoma. Clinical trials in patients with malignancies are being conducted. (en)
Title	Valproic Acid in the Complex Therapy of Malignant Tumors Valproic Acid in the Complex Therapy of Malignant Tumors (en)
skos:prefLabel	Valproic Acid in the Complex Therapy of Malignant Tumors Valproic Acid in the Complex Therapy of Malignant Tumors (en)
skos:notation	RIV/00216208:11130/10:6055!RIV11-MZ0-11130___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(NR9522), Z(MSM0021620813)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hřebačková, Jana Eckschlager, Tomáš Hraběta, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	295221
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/10:6055
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Valproic acid; histone deacetylase inhibitors; antiangiogenic effect; anticancer effect; clinical studies; histone deacetylase inhibitors; acute myeloid-leukemia; trans-retinoic acid; nitric-oxide synthase; human neuroblastoma-cells; hematopoietic stem-cells; prostate-cancer cells; growth in-vitro; nf-kappa-b; gene-expression (en)
http://linked.open.../riv/klicoveSlovo	gene-expression nf-kappa-b trans-retinoic acid acute myeloid-leukemia nitric-oxide synthase antiangiogenic effect anticancer effect growth in-vitro human neuroblastoma-cells prostate-cancer cells hematopoietic stem-cells clinical studies Valproic acid histone deacetylase inhibitors
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[814956D295D2]
http://linked.open...i/riv/nazevZdroje	Current Drug Targets
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Potentiation of cytostatics effects by valproic acid
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Eckschlager, Tomáš Hraběta, Jan Hřebačková, Jana
http://linked.open...ain/vavai/riv/wos	000274419800010
http://linked.open...n/vavai/riv/zamer	The Molecular Basis of Childhood Malignancies and Therapeutic Applications
issn	1389-4501
number of pages	19 (xsd:int)
http://localhost/t...ganizacniJednotka	11130
is http://linked.open...avai/riv/vysledek of	Valproic Acid in the Complex Therapy of Malignant Tumors Valproic Acid in the Complex Therapy of Malignant Tumors Valproic Acid in the Complex Therapy of Malignant Tumors

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