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rdf:type
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Description
| - Distinction between grade II ependymomas and anaplastic ependymomas based on histopathological examination solely is problematic. Therefore, we performed systematic review (SR) and meta-analysis (MA) of data published on immunohistochemical prognostic markers (IPM) in intracranial ependymomas (IE) in order to establish an evidence-based perspective on their clinical value. 30 studies reporting results on IPM in IE were identified. Due to a pronounced inter-study heterogeneity, only 14 publications fulfilled the criteria for inclusion into SR. From the total of 67 immunohistochemical markers, 18 were found to correlate with prognosis. However, due to inadequate data publishing, MA could be performed only with data on proliferation marker MIB-1 (Ki-67) from 5 publications, including 337 patients: The pooled hazard ratio for overall survival was 3.16 (95% confidence interval = 1.96 – 5.09; p < 0.001) implicating that patients with tumors with higher expression of MIB-1 had a significantly worse outcome.
- Distinction between grade II ependymomas and anaplastic ependymomas based on histopathological examination solely is problematic. Therefore, we performed systematic review (SR) and meta-analysis (MA) of data published on immunohistochemical prognostic markers (IPM) in intracranial ependymomas (IE) in order to establish an evidence-based perspective on their clinical value. 30 studies reporting results on IPM in IE were identified. Due to a pronounced inter-study heterogeneity, only 14 publications fulfilled the criteria for inclusion into SR. From the total of 67 immunohistochemical markers, 18 were found to correlate with prognosis. However, due to inadequate data publishing, MA could be performed only with data on proliferation marker MIB-1 (Ki-67) from 5 publications, including 337 patients: The pooled hazard ratio for overall survival was 3.16 (95% confidence interval = 1.96 – 5.09; p < 0.001) implicating that patients with tumors with higher expression of MIB-1 had a significantly worse outcome. (en)
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Title
| - Immunohistochemical Prognostic Markers in Intracranial Ependymomas: Systematic Review and Meta-Analysis
- Immunohistochemical Prognostic Markers in Intracranial Ependymomas: Systematic Review and Meta-Analysis (en)
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skos:prefLabel
| - Immunohistochemical Prognostic Markers in Intracranial Ependymomas: Systematic Review and Meta-Analysis
- Immunohistochemical Prognostic Markers in Intracranial Ependymomas: Systematic Review and Meta-Analysis (en)
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skos:notation
| - RIV/00216208:11130/09:5715!RIV10-MZ0-11130___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - Z(MSM0021620812), Z(MZ0FNM2005)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11130/09:5715
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Ependymoma; Immunohistochemistry; Ki-67; Meta-analysis; MIB-1; prognosis; ki-67 immunolabeling index; central-nervous-system; epithelial differentiation; cell-proliferation; labeling index; expression; survival; childhood; tumors; children (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Pathology & Oncology Research
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Janda, Aleš
- Kuncová, Klára
- Zámečník, Josef
- Kasal, Pavel
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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is http://linked.open...avai/riv/vysledek
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