About: Influence of Maternal Hyperglycaemia on Cord Blood Mononuclear Cells in Response to Diabetes-associated Autoantigens

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Little is known how maternal hyperglycaemia influences the specific immune response of her baby. Furthermore, babies of type 1 diabetes (T1D) mothers have less risk of development T1D than babies with a T1D father. This study aimed to analyze the effect of maternal hyperglycaemia on newborns with focus on the response to diabetes-associated autoantigens. Newborns of T1D mothers split into groups according to maternal diabetes compensation during the 3rd trimester,newborns with T1D father, newborns with a mother treated for either gestational or type 2 diabetes and control newborns were studied. A prominent Th1 response (high IFN-gamma) from autoantigen stimulation was observed especially in babies of T1D fathers and also in mothers with perfect diabetes compensation. It seems that maternal 'sweet' as well as 'autoimmune environment' may both lead to lower occurrence of T1D within their offspring. Little is known how maternal hyperglycaemia influences the specific immune response of her baby. Furthermore, babies of type 1 diabetes (T1D) mothers have less risk of development T1D than babies with a T1D father. This study aimed to analyze the effect of maternal hyperglycaemia on newborns with focus on the response to diabetes-associated autoantigens. Newborns of T1D mothers split into groups according to maternal diabetes compensation during the 3rd trimester,newborns with T1D father, newborns with a mother treated for either gestational or type 2 diabetes and control newborns were studied. A prominent Th1 response (high IFN-gamma) from autoantigen stimulation was observed especially in babies of T1D fathers and also in mothers with perfect diabetes compensation. It seems that maternal 'sweet' as well as 'autoimmune environment' may both lead to lower occurrence of T1D within their offspring. (en)
Title	Influence of Maternal Hyperglycaemia on Cord Blood Mononuclear Cells in Response to Diabetes-associated Autoantigens Influence of Maternal Hyperglycaemia on Cord Blood Mononuclear Cells in Response to Diabetes-associated Autoantigens (en)
skos:prefLabel	Influence of Maternal Hyperglycaemia on Cord Blood Mononuclear Cells in Response to Diabetes-associated Autoantigens Influence of Maternal Hyperglycaemia on Cord Blood Mononuclear Cells in Response to Diabetes-associated Autoantigens (en)
skos:notation	RIV/00216208:11130/09:5366!RIV10-MZ0-11130___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZ0FNM2005)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Špálová, Ivana Šťavíková, Vendula Durilová, Marianna Štechová, Kateřina Ulmannová, Tereza Piťhová, Pavlína Černý, Miloš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	319281
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/09:5366
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	t-cells; mothers; pregnancy; children; newborns; mellitus; fathers; risk (en)
http://linked.open.../riv/klicoveSlovo	mellitus children pregnancy risk t-cells mothers fathers newborns
http://linked.open...odStatuVydavatele	NO - Norské království
http://linked.open...ontrolniKodProRIV	[6C5CF57A1DBC]
http://linked.open...i/riv/nazevZdroje	Scandinavian Journal of Immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	70
http://linked.open...iv/tvurceVysledku	Durilová, Marianna Štechová, Kateřina Černý, Miloš Piťhová, Pavlína Faresjo, M. Chudoba, Daniel Bartášková, Dagmar Ulmannová, Tereza Špálová, Ivana Cerna, M. Šťavíková, Vendula
http://linked.open...ain/vavai/riv/wos	000268061600010
http://linked.open...n/vavai/riv/zamer	Zdokonalení časné diagnostiky, prevence a léčby těžkých vrozených vývojových vad a chorob geneticky podmíněných či s genetickou dispozicí v prenatální a postnatální fázi vývoje
issn	0300-9475
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	11130
is http://linked.open...avai/riv/vysledek of	Influence of Maternal Hyperglycaemia on Cord Blood Mononuclear Cells in Response to Diabetes-associated Autoantigens Influence of Maternal Hyperglycaemia on Cord Blood Mononuclear Cells in Response to Diabetes-associated Autoantigens Influence of Maternal Hyperglycaemia on Cord Blood Mononuclear Cells in Response to Diabetes-associated Autoantigens Influence of Maternal Hyperglycaemia on Cord Blood Mononuclear Cells in Response to Diabetes-associated Autoantigens

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