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  • Background: Focal cortical dysplasia (FCD) is recognized as the major cause of focal intractable epilepsy in childhood. Various factors influencing postsurgical seizure outcome in pediatric patients with FCD have been reported. Objective: To analyze different variables in relation to seizure outcome in order to identify prognostic factors for selection of pediatric patients with FCD for epilepsy surgery. Methods: A cohort of 149 patients with histologically confirmed mild malformations of cortical development or FCD with at least 2 years of postoperative follow-up was retrospectively studied; 113 subjects had at least 5 years of postoperative follow-up. Twenty-eight clinical, EEG, MRI, neuropsychological, surgical, and histopathologic parameters were evaluated. Results: The only significant predictor of surgical success was completeness of surgical resection, defined as complete removal of the structural MRI lesion (if present) and the cortical region exhibiting prominent ictal and interictal abnormal
  • Background: Focal cortical dysplasia (FCD) is recognized as the major cause of focal intractable epilepsy in childhood. Various factors influencing postsurgical seizure outcome in pediatric patients with FCD have been reported. Objective: To analyze different variables in relation to seizure outcome in order to identify prognostic factors for selection of pediatric patients with FCD for epilepsy surgery. Methods: A cohort of 149 patients with histologically confirmed mild malformations of cortical development or FCD with at least 2 years of postoperative follow-up was retrospectively studied; 113 subjects had at least 5 years of postoperative follow-up. Twenty-eight clinical, EEG, MRI, neuropsychological, surgical, and histopathologic parameters were evaluated. Results: The only significant predictor of surgical success was completeness of surgical resection, defined as complete removal of the structural MRI lesion (if present) and the cortical region exhibiting prominent ictal and interictal abnormal (en)
Title
  • Incomplete resection of focal cortical dysplasia is the main predictor of poor postsurgical outcome
  • Incomplete resection of focal cortical dysplasia is the main predictor of poor postsurgical outcome (en)
skos:prefLabel
  • Incomplete resection of focal cortical dysplasia is the main predictor of poor postsurgical outcome
  • Incomplete resection of focal cortical dysplasia is the main predictor of poor postsurgical outcome (en)
skos:notation
  • RIV/00216208:11130/09:5354!RIV10-MZ0-11130___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NR8843), Z(MZ0FNM2005)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 318961
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11130/09:5354
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • pediatric epilepsy surgery; surgical-treatment; intractable epilepsy; intrinsic epileptogenicity; children; malformations; lesions; eeg; classification; subtypes (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [EDCDA7E01E2E]
http://linked.open...i/riv/nazevZdroje
  • Neurology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 72
http://linked.open...iv/tvurceVysledku
  • Kršek, Pavel
  • Vinters, HV
  • Duchowny, M.
  • Dean, P.
  • Dunoyer, C.
  • Jayakar, P.
  • Korman, B.
  • Maton, B.
  • Resnick, T.
  • Rey, G.
  • Morrison, G.
  • Ragheb, J.
  • Pacheco-Jacome, E.
http://linked.open...ain/vavai/riv/wos
  • 000262624300005
http://linked.open...n/vavai/riv/zamer
issn
  • 0028-3878
number of pages
http://localhost/t...ganizacniJednotka
  • 11130
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