About: Profiling proteinuria in children after renal transplantation

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Proteinuria is a common complication after renal transplantation (RTx). In adults, tubular proteinuria prevails and is associated with impaired graft survival. In the absence of studies on proteinuria profiling in transplanted children, we aimed at analyzing the types of proteinuria in transplanted children. Fifty-three children (11.8 years) were analyzed in a cross-sectional study. Morning urine was tested for total protein (PROT), albumin (ALB) and alpha-1-microglobulin (AMG). The type of proteinuria was assessed by the alpha-1-microglobulin/albumin algorithm (AAA): [AAA = AMG x 100/(AMG+ALB]. Median PROT, ALB, and AMG (in mg/mmol creatinine) were 20.0, 3.8, and 4.9, respectively. Pathological total proteinuria (> 22 mg protein/mmol creatinine) was found in 47% of children (25/53). Only 20% of patients with pathological total proteinuria (5/25) had glomerular proteinuria, whereas 80% (20/25) had tubular proteinuria. Proteinuria is a common complication after renal transplantation (RTx). In adults, tubular proteinuria prevails and is associated with impaired graft survival. In the absence of studies on proteinuria profiling in transplanted children, we aimed at analyzing the types of proteinuria in transplanted children. Fifty-three children (11.8 years) were analyzed in a cross-sectional study. Morning urine was tested for total protein (PROT), albumin (ALB) and alpha-1-microglobulin (AMG). The type of proteinuria was assessed by the alpha-1-microglobulin/albumin algorithm (AAA): [AAA = AMG x 100/(AMG+ALB]. Median PROT, ALB, and AMG (in mg/mmol creatinine) were 20.0, 3.8, and 4.9, respectively. Pathological total proteinuria (> 22 mg protein/mmol creatinine) was found in 47% of children (25/53). Only 20% of patients with pathological total proteinuria (5/25) had glomerular proteinuria, whereas 80% (20/25) had tubular proteinuria. (en)
Title	Profiling proteinuria in children after renal transplantation Profiling proteinuria in children after renal transplantation (en)
skos:prefLabel	Profiling proteinuria in children after renal transplantation Profiling proteinuria in children after renal transplantation (en)
skos:notation	RIV/00216208:11130/09:5323!RIV10-MZ0-11130___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR9524), Z(MSM0021620819)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Vondrák, Karel Seeman, Tomáš Špatenka, Jaroslav Dušek, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 2. lékařská fakulta
http://linked.open...dnocenehoVysledku	336846
http://linked.open...ai/riv/idVysledku	RIV/00216208:11130/09:5323
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Tubular proteinuria; Glomerular proteinuria; Renal transplantation; Children; Albuminuria; Alpha-1-microglobulin; kidney-transplantation; recipients; survival; histopathology; adolescents; excretion; sirolimus; blockade; diseases; albumin (en)
http://linked.open.../riv/klicoveSlovo	blockade Children albumin excretion Renal transplantation kidney-transplantation histopathology survival Alpha-1-microglobulin adolescents sirolimus diseases recipients Albuminuria Glomerular proteinuria Tubular proteinuria
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1695707E817C]
http://linked.open...i/riv/nazevZdroje	Pediatric Nephrology
http://linked.open...in/vavai/riv/obor	FG
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Treatment of proteinuria and hypertension with angiotensin-converting enzyme inhibitor in children after renal transplantation
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Dušek, Jiří Vondrák, Karel Špatenka, Jaroslav Seeman, Tomáš Feber, J.
http://linked.open...ain/vavai/riv/wos	000271283400021
http://linked.open...n/vavai/riv/zamer	Náhrada a podpora funkce některých životně důležitých orgánů
issn	0931-041X
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	11130
is http://linked.open...avai/riv/vysledek of	Profiling proteinuria in children after renal transplantation Profiling proteinuria in children after renal transplantation Profiling proteinuria in children after renal transplantation Profiling proteinuria in children after renal transplantation

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