About: Differences in maternal behavior and development of their pups depend on the time of methamphetamine exposure during gestation period

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About: Differences in maternal behavior and development of their pups depend on the time of methamphetamine exposure during gestation period Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The present study examined the hypothesis that the extension of noxious effect of methamphetamine (MA) on maternal behavior and postnatal development on the pups may differ in dependence with time of application. Female rats were injected with MA (5 mg/kg) or saline during first (embryonic day (ED) 1-11) or second (ED 12-22) half of gestation. Our results demonstrated that MA exposure on ED 12-22 led to decreased birth weight and weight gained during lactation period relative to rats treated on ED 1-11. Both sexes treated prenatally with MA on ED 1-11 opened eyes earlier compared to animals treated on ED 12-22. As a matter of sensorimotor development application of MA on ED 1-11 impaired the righting reflex, while MA exposure on ED 12-22 impaired the performance of beam balance test in male rats. There were no differences in maternal behavior. Therefore, it seems that MA exposure in the first half of the gestation impaired the early sensorimotor development that is under control of the brain stem, while the MA exposure in the second half of gestation affected the beam balance performance that is dependent on the function of the cerebellum. The present study examined the hypothesis that the extension of noxious effect of methamphetamine (MA) on maternal behavior and postnatal development on the pups may differ in dependence with time of application. Female rats were injected with MA (5 mg/kg) or saline during first (embryonic day (ED) 1-11) or second (ED 12-22) half of gestation. Our results demonstrated that MA exposure on ED 12-22 led to decreased birth weight and weight gained during lactation period relative to rats treated on ED 1-11. Both sexes treated prenatally with MA on ED 1-11 opened eyes earlier compared to animals treated on ED 12-22. As a matter of sensorimotor development application of MA on ED 1-11 impaired the righting reflex, while MA exposure on ED 12-22 impaired the performance of beam balance test in male rats. There were no differences in maternal behavior. Therefore, it seems that MA exposure in the first half of the gestation impaired the early sensorimotor development that is under control of the brain stem, while the MA exposure in the second half of gestation affected the beam balance performance that is dependent on the function of the cerebellum. (en)
Title	Differences in maternal behavior and development of their pups depend on the time of methamphetamine exposure during gestation period Differences in maternal behavior and development of their pups depend on the time of methamphetamine exposure during gestation period (en)
skos:prefLabel	Differences in maternal behavior and development of their pups depend on the time of methamphetamine exposure during gestation period Differences in maternal behavior and development of their pups depend on the time of methamphetamine exposure during gestation period (en)
skos:notation	RIV/00216208:11120/14:43909367!RIV15-MSM-11120___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GA14-03708S), S
http://linked.open...iv/cisloPeriodika	Suppl. 4
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Hrebíčková, Ivana Malinová-Ševčíková, Mária Pometlová, Marie Šlamberová, Romana Macúchová, Eva Nová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	11431
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/14:43909367
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	critical developmental periods; sensorimotor development; maternal behavior; methamphetamine; psychostimulants (en)
http://linked.open.../riv/klicoveSlovo	sensorimotor development critical developmental periods methamphetamine maternal behavior psychostimulants
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[7EF379EE9207]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Urcení kritické vývojové periody pro úcinky metamfetaminu u laboratorního potkana
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	63
http://linked.open...iv/tvurceVysledku	Pometlová, Marie Šlamberová, Romana Macúchová, Eva Nová, Eva Hrebíčková, Ivana Malinová-Ševčíková, Mária
issn	0862-8408
number of pages	14 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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