About: Dual role of host Par2 in a murine model of spontaneous metastatic B16 melanoma

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About: Dual role of host Par2 in a murine model of spontaneous metastatic B16 melanoma Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Aim: We investigated differences of metastatic spread of normal proteinase-activated receptor-2 (Par2(+/+)) melanoma B16 in Par2(-/-) (knock-out) animals compared to C57Bl6 mice. Materials and Methods: Nine knock-out mice B6.Cg-F2rl1tm1Mslb/J (Par2(-/-)) and nine C57Bl6/J controls were subcutaneously inoculated with B16 melanoma tissue cells. Twelve days after inoculation, all primary tumors were removed. Survival and metastatic spread was followed for up to 100 days after primary tumor extirpation. Results: Excised primary tumors were on average larger in Par2(-/-) mice (360 mm(3) vs. 221 mm(3) in C57Bl6/J). Distant spontaneous metastases developed in only 3 of 9 of Par2(-/-) mice in comparison to 6 of 9 controls. The average survival time was 84 days in Par2(-/-) animals compared to 63 days in C57Bl6/J mice. Conclusion: Host Par2 melanoma model contributes to the limitation of local cancer progression in one area, while on the other hand is important for enhancing distant metastatic spread. Aim: We investigated differences of metastatic spread of normal proteinase-activated receptor-2 (Par2(+/+)) melanoma B16 in Par2(-/-) (knock-out) animals compared to C57Bl6 mice. Materials and Methods: Nine knock-out mice B6.Cg-F2rl1tm1Mslb/J (Par2(-/-)) and nine C57Bl6/J controls were subcutaneously inoculated with B16 melanoma tissue cells. Twelve days after inoculation, all primary tumors were removed. Survival and metastatic spread was followed for up to 100 days after primary tumor extirpation. Results: Excised primary tumors were on average larger in Par2(-/-) mice (360 mm(3) vs. 221 mm(3) in C57Bl6/J). Distant spontaneous metastases developed in only 3 of 9 of Par2(-/-) mice in comparison to 6 of 9 controls. The average survival time was 84 days in Par2(-/-) animals compared to 63 days in C57Bl6/J mice. Conclusion: Host Par2 melanoma model contributes to the limitation of local cancer progression in one area, while on the other hand is important for enhancing distant metastatic spread. (en)
Title	Dual role of host Par2 in a murine model of spontaneous metastatic B16 melanoma Dual role of host Par2 in a murine model of spontaneous metastatic B16 melanoma (en)
skos:prefLabel	Dual role of host Par2 in a murine model of spontaneous metastatic B16 melanoma Dual role of host Par2 in a murine model of spontaneous metastatic B16 melanoma (en)
skos:notation	RIV/00216208:11120/14:43908600!RIV15-MSM-11120___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GAP302/10/0346), P(GAP303/12/1791), S
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Matěj, Radoslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	12472
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/14:43908600
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	murine model; metastasis; melanoma; PAR2 (en)
http://linked.open.../riv/klicoveSlovo	PAR2 murine model metastasis melanoma
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[561AA839AC12]
http://linked.open...i/riv/nazevZdroje	Anticancer Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	3D imaging of mitochondrial network and ultrastructure in relation to bioenergetics, hypoxia, and diseases The role of proteinase-activated receptors in pathogenesis of prion diseases
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	34
http://linked.open...iv/tvurceVysledku	Matěj, Radoslav
http://linked.open...ain/vavai/riv/wos	000338780300036
issn	0250-7005
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	11120

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