| Attributes | Values |
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| rdf:type
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| Description
| - Objectives: This study sought to study the performance of nanocrystalline diamond (NCD) coated stainless steel (SS) coronary stent in a pig coronary artery model. Background: Diamond is hard, biocompatible material which offers the possibility of functionalization by covalent carbon chemistry. Methods: Unique microwave plasma enhanced chemical vapour deposition system enabled NCD coating of SS coronary stents. 26 coronary stents (13 NCD coated and 13 SS) were implanted in a randomized fashion into pig coronary arteries with balloon/artery ratio equal to 1.2. The area of neointimal hyperplasia, late loss and stent strut apposition was evaluated by optical coherence tomography at 6 weeks. Results: All animals survived and all stents were patent at 6 weeks. There was a significantly larger lumen area in the NCD group (4.8±0.97 versus 3.85±0.87 mm2, p=0.02). The neointimal hyperplasia area was smaller in the NCD group by 37% (1.57±0.63 mm2 in NCD group versus 2.39±0.87 mm2 in SS group, p=0.02). There was no difference in stent strut apposition and coverage between NCD and SS group. Conclusion: Implantation of nanocrystalline diamond coated coronary stent significantly reduces neointimal hyperplasia by 37% in comparison to identical stainless steel stent and appears to be safe with very low incidence of non-apposed or uncovered struts.
- Objectives: This study sought to study the performance of nanocrystalline diamond (NCD) coated stainless steel (SS) coronary stent in a pig coronary artery model. Background: Diamond is hard, biocompatible material which offers the possibility of functionalization by covalent carbon chemistry. Methods: Unique microwave plasma enhanced chemical vapour deposition system enabled NCD coating of SS coronary stents. 26 coronary stents (13 NCD coated and 13 SS) were implanted in a randomized fashion into pig coronary arteries with balloon/artery ratio equal to 1.2. The area of neointimal hyperplasia, late loss and stent strut apposition was evaluated by optical coherence tomography at 6 weeks. Results: All animals survived and all stents were patent at 6 weeks. There was a significantly larger lumen area in the NCD group (4.8±0.97 versus 3.85±0.87 mm2, p=0.02). The neointimal hyperplasia area was smaller in the NCD group by 37% (1.57±0.63 mm2 in NCD group versus 2.39±0.87 mm2 in SS group, p=0.02). There was no difference in stent strut apposition and coverage between NCD and SS group. Conclusion: Implantation of nanocrystalline diamond coated coronary stent significantly reduces neointimal hyperplasia by 37% in comparison to identical stainless steel stent and appears to be safe with very low incidence of non-apposed or uncovered struts. (en)
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| Title
| - Novel Nanocrystalline Diamond Coating of Coronary Stents Reduces Neointimal Hyperplasia in Pig Model
- Novel Nanocrystalline Diamond Coating of Coronary Stents Reduces Neointimal Hyperplasia in Pig Model (en)
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| skos:prefLabel
| - Novel Nanocrystalline Diamond Coating of Coronary Stents Reduces Neointimal Hyperplasia in Pig Model
- Novel Nanocrystalline Diamond Coating of Coronary Stents Reduces Neointimal Hyperplasia in Pig Model (en)
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| skos:notation
| - RIV/00216208:11120/14:43908387!RIV15-MSM-11120___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/14:43908387
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Diamond; Optical coherence tomography; Restenosis; Nanotechnology; Stents (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Experimental and Clinical Cardiology
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kočka, Viktor
- Toušek, Petr
- Mandys, Václav
- Jirásek, Tomáš
|
| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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