About: Current Concepts in the Classification and Diagnosis of Frontotemporal Lobar Degenerations A Practical Approach

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Frontotemporal lobar degenerations are clinically, genetically, and molecularly heterogeneous diseases characterized by mainly frontal and temporal atrophy and affecting behavioral, language, cognitive, and motor functions. The term frontotemporal dementia incorporates 3 distinct clinical syndromes seen in frontotemporal degenerations: behavioral variant of frontotemporal dementia, progressive nonfluent aphasia, and semantic dementia. Progressive supranuclear palsy syndrome, corticobasal syndrome, and motor neuron disease syndrome are also associated with frontotemporal lobar degenerations. The neuropathologic hallmark of frontotemporal lobar degenerations is accumulation of abnormal proteins in the cytoplasm and nuclei of neurons and glial cells. Proteins involved in pathologic processes that represent the basis for frontotemporal lobar degeneration classification are tau protein, transactive response DNA-binding protein of 43 kDa, and %22fused in sarcoma%22 protein. The aim of this review is to provide a summary of practical approaches for neuropathologic diagnostics of the rapidly evolving classifications of frontotemporal lobar degenerations Frontotemporal lobar degenerations are clinically, genetically, and molecularly heterogeneous diseases characterized by mainly frontal and temporal atrophy and affecting behavioral, language, cognitive, and motor functions. The term frontotemporal dementia incorporates 3 distinct clinical syndromes seen in frontotemporal degenerations: behavioral variant of frontotemporal dementia, progressive nonfluent aphasia, and semantic dementia. Progressive supranuclear palsy syndrome, corticobasal syndrome, and motor neuron disease syndrome are also associated with frontotemporal lobar degenerations. The neuropathologic hallmark of frontotemporal lobar degenerations is accumulation of abnormal proteins in the cytoplasm and nuclei of neurons and glial cells. Proteins involved in pathologic processes that represent the basis for frontotemporal lobar degeneration classification are tau protein, transactive response DNA-binding protein of 43 kDa, and %22fused in sarcoma%22 protein. The aim of this review is to provide a summary of practical approaches for neuropathologic diagnostics of the rapidly evolving classifications of frontotemporal lobar degenerations (en)
Title	Current Concepts in the Classification and Diagnosis of Frontotemporal Lobar Degenerations A Practical Approach Current Concepts in the Classification and Diagnosis of Frontotemporal Lobar Degenerations A Practical Approach (en)
skos:prefLabel	Current Concepts in the Classification and Diagnosis of Frontotemporal Lobar Degenerations A Practical Approach Current Concepts in the Classification and Diagnosis of Frontotemporal Lobar Degenerations A Practical Approach (en)
skos:notation	RIV/00216208:11120/14:43907956!RIV15-MSM-11120___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Rohan, Zdeněk Matěj, Radoslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	9417
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/14:43907956
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	practical approach; frontotemporal lobar degenerations; diagnosis; classification (en)
http://linked.open.../riv/klicoveSlovo	classification diagnosis frontotemporal lobar degenerations practical approach
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[07CBFC9CF316]
http://linked.open...i/riv/nazevZdroje	Archives of Pathology & Laboratory Medicine
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	138
http://linked.open...iv/tvurceVysledku	Matěj, Radoslav Rohan, Zdeněk
http://linked.open...ain/vavai/riv/wos	000339549400020
issn	0003-9985
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.5858/arpa.2012-0510-RS
http://localhost/t...ganizacniJednotka	11120

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