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  • The aim of this study was to investigate regularity in the daily mood stabilizer dosage taken by patients with bipolar disorder, and identify factors associated with irregularity. Self-reported daily mood and medication data were available from 206 patients who took the same mood stabilizer for >= 100 days. Approximate entropy (ApEn) was used to measure serial regularity in daily mood stabilizer dosage. Generalized estimating equations (GEE) were used to estimate if demographic or clinical variables were associated with ApEn. Results: There was a wide range of regularity in the daily mood stabilizer dosage. The mean per-cent of days of missing doses was 13.6 %. The number of psychotropic medications (p = 0.007), pill burden (p = 0.004) and percent of days with depressed mood (p = 0.013) were associated with more irregularity, while the percent of days euthymic (p = 0.014) was associated with less irregularity. The percent of days missing doses was not associated with the number of medications, pill burden or mood ratings. Discussion: Patients may have irregularity in daily dosage in spite of a low percent of days missing doses. Psychotropic medication regimen complexity and depression are associated with increased dosage irregularity. Research is needed on how irregularity in daily dosage impacts the continuity of drug action of mood stabilizers.
  • The aim of this study was to investigate regularity in the daily mood stabilizer dosage taken by patients with bipolar disorder, and identify factors associated with irregularity. Self-reported daily mood and medication data were available from 206 patients who took the same mood stabilizer for >= 100 days. Approximate entropy (ApEn) was used to measure serial regularity in daily mood stabilizer dosage. Generalized estimating equations (GEE) were used to estimate if demographic or clinical variables were associated with ApEn. Results: There was a wide range of regularity in the daily mood stabilizer dosage. The mean per-cent of days of missing doses was 13.6 %. The number of psychotropic medications (p = 0.007), pill burden (p = 0.004) and percent of days with depressed mood (p = 0.013) were associated with more irregularity, while the percent of days euthymic (p = 0.014) was associated with less irregularity. The percent of days missing doses was not associated with the number of medications, pill burden or mood ratings. Discussion: Patients may have irregularity in daily dosage in spite of a low percent of days missing doses. Psychotropic medication regimen complexity and depression are associated with increased dosage irregularity. Research is needed on how irregularity in daily dosage impacts the continuity of drug action of mood stabilizers. (en)
Title
  • Regularity in Daily Mood Stabilizer Dosage Taken by Patients with Bipolar Disorder
  • Regularity in Daily Mood Stabilizer Dosage Taken by Patients with Bipolar Disorder (en)
skos:prefLabel
  • Regularity in Daily Mood Stabilizer Dosage Taken by Patients with Bipolar Disorder
  • Regularity in Daily Mood Stabilizer Dosage Taken by Patients with Bipolar Disorder (en)
skos:notation
  • RIV/00216208:11120/13:43908359!RIV14-MSM-11120___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 102062
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/13:43908359
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • dosage; mood stabilizers; bipolar disorder (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [192417846A61]
http://linked.open...i/riv/nazevZdroje
  • Pharmacopsychiatry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 46
http://linked.open...iv/tvurceVysledku
  • Alda, Martin
http://linked.open...ain/vavai/riv/wos
  • 000321340800001
issn
  • 0176-3679
number of pages
http://localhost/t...ganizacniJednotka
  • 11120
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