About: The effect of vitamin E on plasmatic malondialdehyde levels during surgical removal of ovarian and endometrial carcinomas     Goto   Sponge   NotDistinct   Permalink

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  • This study deals with the monitoring of the plasmatic level of malondialdehyde, as the main indicator of oxidative damage to biomembranes. Malondialdehyde is determined by HPLC after derivatization employing 2,4-dinitrophenylhydrazine. A clinical study involving 20 female patients suffering from ovarian and endometrical carcinomas has demonstrated elevated levels of malondialdehyde (10.1 ± 1.1 µM), compared with the control group (7.5 ± 2.7 µM). It has been further verified that surgical removal of the tumor leads to an additional increase in the plasmatic malondialdehyde content. This unfavourable situation can be effectively eliminated by administration of a single dose of vitamin E prior to surgery.
  • This study deals with the monitoring of the plasmatic level of malondialdehyde, as the main indicator of oxidative damage to biomembranes. Malondialdehyde is determined by HPLC after derivatization employing 2,4-dinitrophenylhydrazine. A clinical study involving 20 female patients suffering from ovarian and endometrical carcinomas has demonstrated elevated levels of malondialdehyde (10.1 ± 1.1 µM), compared with the control group (7.5 ± 2.7 µM). It has been further verified that surgical removal of the tumor leads to an additional increase in the plasmatic malondialdehyde content. This unfavourable situation can be effectively eliminated by administration of a single dose of vitamin E prior to surgery. (en)
Title
  • The effect of vitamin E on plasmatic malondialdehyde levels during surgical removal of ovarian and endometrial carcinomas
  • The effect of vitamin E on plasmatic malondialdehyde levels during surgical removal of ovarian and endometrial carcinomas (en)
skos:prefLabel
  • The effect of vitamin E on plasmatic malondialdehyde levels during surgical removal of ovarian and endometrial carcinomas
  • The effect of vitamin E on plasmatic malondialdehyde levels during surgical removal of ovarian and endometrial carcinomas (en)
skos:notation
  • RIV/00216208:11120/13:43907489!RIV14-MSM-11120___
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  • I
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  • 4
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  • 71829
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  • RIV/00216208:11120/13:43907489
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  • Gynaecology.; Vitamin E; Malondialdehyde; Lipid peroxidation; Cancer (en)
http://linked.open.../riv/klicoveSlovo
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  • CA - Kanada
http://linked.open...ontrolniKodProRIV
  • [709C76F0D9B1]
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  • European Journal of Gynaecological Oncology
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  • 34
http://linked.open...iv/tvurceVysledku
  • Samcová, Eva
  • Tůma, Petr
  • Rokyta, Richard
  • Matějčková, Jana
  • Samec, Martin
issn
  • 0392-2936
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  • 11120
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