About: New therapy of pleural empyema by deoxyribonuclease     Goto   Sponge   NotDistinct   Permalink

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  • Empyema is a severe complication of different diseases and traumas. Management of this complication is difficult and should comprise general and local procedures. The general procedure is mainly based on administering wide-spectrum antibiotics. Local management depends on patient general condition, but in all cases the essential procedure is to insert a drain into the pleural cavity and to evacuate the pus. Sometimes pus is very thick and its evacuation and following re-expansion of the lung is rather impossible. In these patients surgical intervention is needed. The use of intrapleural enzymes to support the drainage was first described in 1949 by Tillett and Sherry using a mixture of streptokinase and streptococcal deoxyribonuclease. Nowadays, purified streptokinase has come into widespread use, but recent studies reported no streptokinase effect on pus viscosity. On the other side, deoxyribonuclease reduces pus viscosity and may be more useful in treatment. We report two cases of intrapleural administration of Pulmozyme (alfa dornase - deoxyribonuclease (HOFFMANN-LA ROCHE AG) in dosage 2 x 2.5 mg with a significant improvement caused by changes in pus viscosity.
  • Empyema is a severe complication of different diseases and traumas. Management of this complication is difficult and should comprise general and local procedures. The general procedure is mainly based on administering wide-spectrum antibiotics. Local management depends on patient general condition, but in all cases the essential procedure is to insert a drain into the pleural cavity and to evacuate the pus. Sometimes pus is very thick and its evacuation and following re-expansion of the lung is rather impossible. In these patients surgical intervention is needed. The use of intrapleural enzymes to support the drainage was first described in 1949 by Tillett and Sherry using a mixture of streptokinase and streptococcal deoxyribonuclease. Nowadays, purified streptokinase has come into widespread use, but recent studies reported no streptokinase effect on pus viscosity. On the other side, deoxyribonuclease reduces pus viscosity and may be more useful in treatment. We report two cases of intrapleural administration of Pulmozyme (alfa dornase - deoxyribonuclease (HOFFMANN-LA ROCHE AG) in dosage 2 x 2.5 mg with a significant improvement caused by changes in pus viscosity. (en)
Title
  • New therapy of pleural empyema by deoxyribonuclease
  • New therapy of pleural empyema by deoxyribonuclease (en)
skos:prefLabel
  • New therapy of pleural empyema by deoxyribonuclease
  • New therapy of pleural empyema by deoxyribonuclease (en)
skos:notation
  • RIV/00216208:11120/13:43907204!RIV13-MSM-11120___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 91703
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/13:43907204
http://linked.open...riv/jazykVysledku
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  • Deoxyribonuclease; Viscosity; Lung; Empyema (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • BR - Brazilská federativní republika
http://linked.open...ontrolniKodProRIV
  • [D04991FC1AD3]
http://linked.open...i/riv/nazevZdroje
  • Brazilian Journal of Infectious Diseases
http://linked.open...in/vavai/riv/obor
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 17
http://linked.open...iv/tvurceVysledku
  • Bobek, Vladimír
  • Gürlich, Robert
http://linked.open...ain/vavai/riv/wos
  • 000315068200015
issn
  • 1413-8670
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.bjid.2012.08.019
http://localhost/t...ganizacniJednotka
  • 11120
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