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| Description
| - We read with great interest the article by Wygrecka and colleagues in the June 15, 2011 issue of the Journal regarding the role of proteinase-activated receptor (PAR)-2 in idiopathic pulmonary fibrosis (IPF). In the discussion, the authors expressed “such a surprise” at finding PAR-2-/- mice were not protected from bleomycin-induced pulmonary fibrosis (BIF). This view comes from a misunderstanding of PAR-2 as a %22specific effector%22 in IPF and BIF. There is no doubt about the excellent results presented; however, increased expression, up-regulation by transforming growth factor (TGF)-beta1, and the necessity of PAR-2 for human lung fibroblasts proliferation doesn´t mean that this receptor is essential for IPF/BIF induction or development. Proliferation itself is not self-evident fibrosis. Based on our experiments and the literature, we think that PAR-2 activation is a very important but nonspecific enhancer of different cellular responses resulting from its role in membrane internalization and intracellular sorting. From a phylogenetic point of view and resembling the role of pancreatic trypsin in alimentary digestion, PAR-2 activation could serve as an old cell-feeding mechanism. To sum up, results obtained by Wygrecka and coworkers are challenging and promising, but we doubt that simple blocking of PAR-2 could serve as an effective treatment strategy for IPF considering that the role of PAR-2 in the pathogenesis of IPF is nonspecific and secondarily induced.
- We read with great interest the article by Wygrecka and colleagues in the June 15, 2011 issue of the Journal regarding the role of proteinase-activated receptor (PAR)-2 in idiopathic pulmonary fibrosis (IPF). In the discussion, the authors expressed “such a surprise” at finding PAR-2-/- mice were not protected from bleomycin-induced pulmonary fibrosis (BIF). This view comes from a misunderstanding of PAR-2 as a %22specific effector%22 in IPF and BIF. There is no doubt about the excellent results presented; however, increased expression, up-regulation by transforming growth factor (TGF)-beta1, and the necessity of PAR-2 for human lung fibroblasts proliferation doesn´t mean that this receptor is essential for IPF/BIF induction or development. Proliferation itself is not self-evident fibrosis. Based on our experiments and the literature, we think that PAR-2 activation is a very important but nonspecific enhancer of different cellular responses resulting from its role in membrane internalization and intracellular sorting. From a phylogenetic point of view and resembling the role of pancreatic trypsin in alimentary digestion, PAR-2 activation could serve as an old cell-feeding mechanism. To sum up, results obtained by Wygrecka and coworkers are challenging and promising, but we doubt that simple blocking of PAR-2 could serve as an effective treatment strategy for IPF considering that the role of PAR-2 in the pathogenesis of IPF is nonspecific and secondarily induced. (en)
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| Title
| - The role of proteinase-activated receptor-2 in idiopathic pulmonary fibrosis: is there really novel therapeutic potential here?
- The role of proteinase-activated receptor-2 in idiopathic pulmonary fibrosis: is there really novel therapeutic potential here? (en)
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| skos:prefLabel
| - The role of proteinase-activated receptor-2 in idiopathic pulmonary fibrosis: is there really novel therapeutic potential here?
- The role of proteinase-activated receptor-2 in idiopathic pulmonary fibrosis: is there really novel therapeutic potential here? (en)
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| skos:notation
| - RIV/00216208:11120/12:43907117!RIV13-MSM-11120___
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| http://linked.open...avai/predkladatel
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/12:43907117
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - idiopathic pulmonary fibrosis; receptor-2; proteinase-activated (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - American Journal of Respiratory and Critical Care Medicine
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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