About: Anxiogenic Effect of low-dose methamphetamine in the test of Elevated plus-maze

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://pmr.cuni.cz/file/5632/PMR2012A0022.pdf
Description	Methamphetamines (MA) are psychostimulant drugs that are known to change individuals' behavior. Psychostimulants could either evoke positive emotions (e.g. joy and happiness) or attenuate negative emotional states (e.g. anxiety and depression) in humans. In animal experiments, the test of elevated plus-maze (EPM) is widely used. This test is appropriate for evaluation of anxiolytic and anxiogenic drug effects, or for examination of specific subtypes of anxiety disorders. The aim of the present study was to examine the effect of acute single dose of MA (1 mg/kg) on the behavior of laboratory rat in the EPM. The detailed ethologic analysis of behavior was performed using a modified protocol based on the study of Fernández Espejo (1997). Our results demonstrated that MA affects rat's behavior in the EPM in the majority of analyzed categories. The present protocol allowed us to determine positive anxiogenic effect of MA. Methamphetamines (MA) are psychostimulant drugs that are known to change individuals' behavior. Psychostimulants could either evoke positive emotions (e.g. joy and happiness) or attenuate negative emotional states (e.g. anxiety and depression) in humans. In animal experiments, the test of elevated plus-maze (EPM) is widely used. This test is appropriate for evaluation of anxiolytic and anxiogenic drug effects, or for examination of specific subtypes of anxiety disorders. The aim of the present study was to examine the effect of acute single dose of MA (1 mg/kg) on the behavior of laboratory rat in the EPM. The detailed ethologic analysis of behavior was performed using a modified protocol based on the study of Fernández Espejo (1997). Our results demonstrated that MA affects rat's behavior in the EPM in the majority of analyzed categories. The present protocol allowed us to determine positive anxiogenic effect of MA. (en)
Title	Anxiogenic Effect of low-dose methamphetamine in the test of Elevated plus-maze Anxiogenic Effect of low-dose methamphetamine in the test of Elevated plus-maze (en)
skos:prefLabel	Anxiogenic Effect of low-dose methamphetamine in the test of Elevated plus-maze Anxiogenic Effect of low-dose methamphetamine in the test of Elevated plus-maze (en)
skos:notation	RIV/00216208:11120/12:43907055!RIV13-MSM-11120___
http://linked.open...avai/predkladatel	3. lékařská fakulta
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GAP303/10/0580), S
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Pometlová, Marie Šlamberová, Romana Deykun, Kateryna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	123048
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/12:43907055
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	methamphetamine; elevated plus-maze; behavior; anxiety (en)
http://linked.open.../riv/klicoveSlovo	anxiety behavior methamphetamine elevated plus-maze
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[950252CCE4FD]
http://linked.open...i/riv/nazevZdroje	Prague Medical Report
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	What is the role of mesolimbic reward circuit in the long-term effect of prenatal methamphetamine exposure in rats?
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	113
http://linked.open...iv/tvurceVysledku	Pometlová, Marie Šlamberová, Romana Nohejlová-Deykun, Kateryna
issn	1214-6994
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Anxiogenic Effect of low-dose methamphetamine in the test of Elevated plus-maze

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