About: Ephedrine accelerates psychomotor recovery from anesthesia in macaque monkeys

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Ephedrine is used in treatment of hypotension during anesthesia. We investigated its effects on the psychomotor recovery and its potential adverse reactions on cardiorespiratory functions in rhesus monkeys. Methods The monkeys received 50 mu g/kg medetomidine, 2.0 mg/kg S-ketamine with 150 IU hyaluronidase i.m. Pulse rate, blood pressure and saturation of haemoglobin were monitored for 20 minutes. Thereafter, 1 mg/kg of ephedrine or a placebo was administered i.m. and behavioural changes, pulse rate, blood pressure and saturation of haemoglobin were monitored every 5 minutes. Results Ephedrine shortened recovery from anaesthesia from 80.4 +/- 25.8 to 14.83 +/- 13.70 minutes. Ephedrine also increased oxygen saturation of haemoglobin and systolic blood pressure and caused significant decrease in pulse rate 5 minutes after its administration. Conclusions Ephedrine can be successfully used to accelerate psychomotor recovery after the use of common anesthetic protocols combining dissociative anesthetic agent and alpha 2-adrenoceptor agonist in primates. Ephedrine is used in treatment of hypotension during anesthesia. We investigated its effects on the psychomotor recovery and its potential adverse reactions on cardiorespiratory functions in rhesus monkeys. Methods The monkeys received 50 mu g/kg medetomidine, 2.0 mg/kg S-ketamine with 150 IU hyaluronidase i.m. Pulse rate, blood pressure and saturation of haemoglobin were monitored for 20 minutes. Thereafter, 1 mg/kg of ephedrine or a placebo was administered i.m. and behavioural changes, pulse rate, blood pressure and saturation of haemoglobin were monitored every 5 minutes. Results Ephedrine shortened recovery from anaesthesia from 80.4 +/- 25.8 to 14.83 +/- 13.70 minutes. Ephedrine also increased oxygen saturation of haemoglobin and systolic blood pressure and caused significant decrease in pulse rate 5 minutes after its administration. Conclusions Ephedrine can be successfully used to accelerate psychomotor recovery after the use of common anesthetic protocols combining dissociative anesthetic agent and alpha 2-adrenoceptor agonist in primates. (en)
Title	Ephedrine accelerates psychomotor recovery from anesthesia in macaque monkeys Ephedrine accelerates psychomotor recovery from anesthesia in macaque monkeys (en)
skos:prefLabel	Ephedrine accelerates psychomotor recovery from anesthesia in macaque monkeys Ephedrine accelerates psychomotor recovery from anesthesia in macaque monkeys (en)
skos:notation	RIV/00216208:11120/12:43906415!RIV13-MZ0-11120___
http://linked.open...avai/predkladatel	3. lékařská fakulta
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NS10503), P(VG20102015014)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Slíva, Jiří Málek, J. Kurzová, Alice Votava, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	134586
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/12:43906415
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	primate; ketamine; ephedrine; anaesthesia; alpha2-adrenergic agonist (en)
http://linked.open.../riv/klicoveSlovo	primate alpha2-adrenergic agonist ephedrine anaesthesia ketamine
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A683026D4452]
http://linked.open...i/riv/nazevZdroje	Journal of Medical Primatology
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Oral premedication for treatment of uncooperative patients Alternative ways of administration of anesthetics in disasters and emergency situation
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	41
http://linked.open...iv/tvurceVysledku	Málek, Jiří Slíva, Jiří Hess, Ladislav Kurzová, Alice Votava, Martin
http://linked.open...ain/vavai/riv/wos	000306734200003
issn	0047-2565
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1600-0684.2012.00545.x
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Ephedrine accelerates psychomotor recovery from anesthesia in macaque monkeys

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