About: The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study

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About: The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1371/journal.pmed.1001106
Description	One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors. We genotyped four 9p21 SNPs in 8,114 individuals from the global INTERHEART study. All four variants were associated with MI, with odds ratios (ORs) of 1.18 to 1.20 (1.85 x 10(-8) <= p <= 5.21 x 10(-7)). A significant interaction (p = 4.0 x 10(-4)) was observed between rs2383206 and a factor-analysis-derived %22prudent%22 diet pattern score, for which a major component was raw vegetables. An effect of 9p21 on MI was observed in the group with a low prudent diet score (OR = 1.32, p = 6.82 x 10(-7)), but the effect was diminished in a step-wise fashion in the medium (OR = 1.17, p = 4.9 x 10(-3)) and high prudent diet s One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors. We genotyped four 9p21 SNPs in 8,114 individuals from the global INTERHEART study. All four variants were associated with MI, with odds ratios (ORs) of 1.18 to 1.20 (1.85 x 10(-8) <= p <= 5.21 x 10(-7)). A significant interaction (p = 4.0 x 10(-4)) was observed between rs2383206 and a factor-analysis-derived %22prudent%22 diet pattern score, for which a major component was raw vegetables. An effect of 9p21 on MI was observed in the group with a low prudent diet score (OR = 1.32, p = 6.82 x 10(-7)), but the effect was diminished in a step-wise fashion in the medium (OR = 1.17, p = 4.9 x 10(-3)) and high prudent diet s (en)
Title	The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study (en)
skos:prefLabel	The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study (en)
skos:notation	RIV/00216208:11120/11:00003516!RIV12-MSM-11120___
http://linked.open...avai/predkladatel	3. lékařská fakulta
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Gregor, P. Widimský, P.
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	196203
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/11:00003516
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Coronary-Artery-Disease; Acute Myocardial-Infarction; Heart-Disease; Risk-Factors; Genomewide Association; 52 Countries; Life-Style (en)
http://linked.open.../riv/klicoveSlovo	52 Countries Acute Myocardial-Infarction Coronary-Artery-Disease Genomewide Association Heart-Disease Life-Style Risk-Factors
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[04407ACB0CA9]
http://linked.open...i/riv/nazevZdroje	PLOS Medicine
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	429 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Widimský, Petr Do, R. Gregor, Pavel
http://linked.open...ain/vavai/riv/wos	000296552400007
issn	1549-1277
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pmed.1001106
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study

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