About: Genetic variation in FOXP2 alters grey matter concentrations in schizophrenia patients

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Genetic variation in FOXP2 alters grey matter concentrations in schizophrenia patients Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.neulet.2011.02.024
Description	FOXP2, the first gene known to be involved in the development of speech and language, can be considered to be, a priori, a candidate gene in schizophrenia, given the mounting evidence that the underlying core deficit in this disease could be a failure of structures relevant to normal language processing. To investigate the potential link between grey matter concentration (GMC) changes in patients with schizophrenia and the FOXP2 rs2396753 polymorphism previously reported to be associated with hallucinations in schizophrenia, we analysed high-resolution anatomical magnetic resonance images of 40 genotyped patients with schizophrenia and 36 healthy controls, using optimised voxel-based morphometry (VBM). Here we show that the common SNP rs2396753 (C > A) gene variant of the FOXP2 gene has significant effects on GMC in patients with schizophrenia, within regions of the brain known to be affected by this disease. Our data suggest that GMC reductions in schizophrenia may be driven by C allele carriers o FOXP2, the first gene known to be involved in the development of speech and language, can be considered to be, a priori, a candidate gene in schizophrenia, given the mounting evidence that the underlying core deficit in this disease could be a failure of structures relevant to normal language processing. To investigate the potential link between grey matter concentration (GMC) changes in patients with schizophrenia and the FOXP2 rs2396753 polymorphism previously reported to be associated with hallucinations in schizophrenia, we analysed high-resolution anatomical magnetic resonance images of 40 genotyped patients with schizophrenia and 36 healthy controls, using optimised voxel-based morphometry (VBM). Here we show that the common SNP rs2396753 (C > A) gene variant of the FOXP2 gene has significant effects on GMC in patients with schizophrenia, within regions of the brain known to be affected by this disease. Our data suggest that GMC reductions in schizophrenia may be driven by C allele carriers o (en)
Title	Genetic variation in FOXP2 alters grey matter concentrations in schizophrenia patients Genetic variation in FOXP2 alters grey matter concentrations in schizophrenia patients (en)
skos:prefLabel	Genetic variation in FOXP2 alters grey matter concentrations in schizophrenia patients Genetic variation in FOXP2 alters grey matter concentrations in schizophrenia patients (en)
skos:notation	RIV/00216208:11120/11:00002944!RIV12-MSM-11120___
http://linked.open...avai/predkladatel	3. lékařská fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(1M0517)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Höschl, Cyril Horáček, Jiří Novák, Tomáš Čermák, Jan Klírová, Monika Španiel, Filip
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	201015
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/11:00002944
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	FOXP2; genetics; grey matter; schizophrenia; VBM; voxel-based morphometry (en)
http://linked.open.../riv/klicoveSlovo	FOXP2 grey matter genetics schizophrenia voxel-based morphometry VBM
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[BB98897CC756]
http://linked.open...i/riv/nazevZdroje	Neuroscience Letters
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	493
http://linked.open...iv/tvurceVysledku	Horáček, Jiří Höschl, Cyril Novák, Tomáš Čermák, Jan Klírová, Monika Španiel, Filip
http://linked.open...ain/vavai/riv/wos	000289582100016
issn	0304-3940
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.neulet.2011.02.024
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Genetic variation in FOXP2 alters grey matter concentrations in schizophrenia patients Genetic variation in FOXP2 alters grey matter concentrations in schizophrenia patients

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software