About: Macrophage gene expression is related to obesity and the metabolic syndrome in human subcutaneous fat as well as in visceral fat

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About: Macrophage gene expression is related to obesity and the metabolic syndrome in human subcutaneous fat as well as in visceral fat Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1007/s00125-010-2014-3
Description	Our goal was to identify a set of human adipose tissue macrophage (ATM)-specific markers and investigate whether their gene expression in subcutaneous adipose tissue (SAT) as well as in visceral adipose tissue (VAT) is related to obesity and to the occurrence of the metabolic syndrome. ATM-specific markers were identified by DNA microarray analysis of adipose tissue cell types isolated from SAT of lean and obese individuals. We then analysed gene expression of these markers by reverse transcription quantitative PCR in paired samples of SAT and VAT from 53 women stratified into four groups (lean, overweight, obese and obese with the metabolic syndrome). Anthropometric measurements, euglycaemic-hyperinsulinaemic clamp, blood analysis and computed tomography scans were performed. A panel of 24 genes was selected as ATM-specific markers based on overexpression in ATM compared with other adipose tissue cell types. Our goal was to identify a set of human adipose tissue macrophage (ATM)-specific markers and investigate whether their gene expression in subcutaneous adipose tissue (SAT) as well as in visceral adipose tissue (VAT) is related to obesity and to the occurrence of the metabolic syndrome. ATM-specific markers were identified by DNA microarray analysis of adipose tissue cell types isolated from SAT of lean and obese individuals. We then analysed gene expression of these markers by reverse transcription quantitative PCR in paired samples of SAT and VAT from 53 women stratified into four groups (lean, overweight, obese and obese with the metabolic syndrome). Anthropometric measurements, euglycaemic-hyperinsulinaemic clamp, blood analysis and computed tomography scans were performed. A panel of 24 genes was selected as ATM-specific markers based on overexpression in ATM compared with other adipose tissue cell types. (en)
Title	Macrophage gene expression is related to obesity and the metabolic syndrome in human subcutaneous fat as well as in visceral fat Macrophage gene expression is related to obesity and the metabolic syndrome in human subcutaneous fat as well as in visceral fat (en)
skos:prefLabel	Macrophage gene expression is related to obesity and the metabolic syndrome in human subcutaneous fat as well as in visceral fat Macrophage gene expression is related to obesity and the metabolic syndrome in human subcutaneous fat as well as in visceral fat (en)
skos:notation	RIV/00216208:11120/11:00002397!RIV12-MZ0-11120___
http://linked.open...avai/predkladatel	3. lékařská fakulta
http://linked.open...avai/riv/aktivita	I P R S
http://linked.open...avai/riv/aktivity	I, P(NR8066), P(NS10519), R, S
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Klimčáková, Eva Kováčiková, Michaela Hejnová, Jindřiška Vedral, Tomáš Štich, Vladimír Kováčová, Zuzana Šiklová-Vítková, Michaela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	210174
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/11:00002397
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Human adipose tissue; Inflammation; Macrophage; Metabolic syndrome; Obesity; Subcutaneous fat; Visceral fat (en)
http://linked.open.../riv/klicoveSlovo	Human adipose tissue Macrophage Subcutaneous fat Visceral fat Inflammation Metabolic syndrome Obesity
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[8FC73C677E03]
http://linked.open...i/riv/nazevZdroje	Diabetologia
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of visceral adipose tissue in ethiopathogenesy of metabolic syndrome investigated on a level of molecular genetic characteristics of tissue Relative abundance of macrophages and other cell populations in adipose tissue in relation to obesity and associated metabolic complications
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	54
http://linked.open...iv/tvurceVysledku	Kováčová, Zuzana Vedral, Tomáš Šiklová-Vítková, Michaela Štich, Vladimír Hejnová, Jindřiška Klimčáková, Eva Kováčiková, Michaela
http://linked.open...ain/vavai/riv/wos	000288217200022
issn	0012-186X
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00125-010-2014-3
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Macrophage gene expression is related to obesity and the metabolic syndrome in human subcutaneous fat as well as in visceral fat Macrophage gene expression is related to obesity and the metabolic syndrome in human subcutaneous fat as well as in visceral fat

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