About: Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1038/ijo.2010.112
Description	Accumulation of adipose tissue macrophages (ATMs) is observed in obesity and may participate in the development of insulin resistance and obesity-related complications. The aim of our study was to investigate the effect of long-term dietary intervention on ATM content in human adipose tissue.Design:We performed a multi-phase longitudinal study. A total of 27 obese pre-menopausal women (age 39+/-2 years, body mass index 33.7+/-0.5 kg m(-2)) underwent a 6-month dietary intervention consisting of two periods: 4 weeks of very low-calorie diet (VLCD) followed by weight stabilization composed of 2 months of low-calorie diet and 3to 4 months of weight maintenance diet. At baseline and at the end of each dietary period, samples of subcutaneous adipose tissue (SAT) were obtained by needle biopsy and blood samples were drawn. ATMs were determined by flow cytometry using combinations of cell surface markers. Selected cytokine and chemokine plasma levels were measured using enzyme-linked immunosorbent assay. Accumulation of adipose tissue macrophages (ATMs) is observed in obesity and may participate in the development of insulin resistance and obesity-related complications. The aim of our study was to investigate the effect of long-term dietary intervention on ATM content in human adipose tissue.Design:We performed a multi-phase longitudinal study. A total of 27 obese pre-menopausal women (age 39+/-2 years, body mass index 33.7+/-0.5 kg m(-2)) underwent a 6-month dietary intervention consisting of two periods: 4 weeks of very low-calorie diet (VLCD) followed by weight stabilization composed of 2 months of low-calorie diet and 3to 4 months of weight maintenance diet. At baseline and at the end of each dietary period, samples of subcutaneous adipose tissue (SAT) were obtained by needle biopsy and blood samples were drawn. ATMs were determined by flow cytometry using combinations of cell surface markers. Selected cytokine and chemokine plasma levels were measured using enzyme-linked immunosorbent assay. (en)
Title	Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women (en)
skos:prefLabel	Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women (en)
skos:notation	RIV/00216208:11120/11:00002392!RIV12-MZ0-11120___
http://linked.open...avai/predkladatel	3. lékařská fakulta
http://linked.open...avai/riv/aktivita	O P
http://linked.open...avai/riv/aktivity	O, P(NS10519)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Klimčáková, Eva Kováčiková, Michaela Bajzová, Magda Hejnová, Jindřiška Rossmeislová, Lenka Štich, Vladimír Kováčová, Zuzana Wedellová, Zuzana Šiklová-Vítková, Michaela Polák, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	194521
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/11:00002392
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	subcutaneous adipose tissue; macrophages; dietary intervention; weight maintenance; obese women (en)
http://linked.open.../riv/klicoveSlovo	dietary intervention macrophages obese women subcutaneous adipose tissue weight maintenance
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[869C1E1A4F7C]
http://linked.open...i/riv/nazevZdroje	International Journal of Obesity
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	10 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	Relative abundance of macrophages and other cell populations in adipose tissue in relation to obesity and associated metabolic complications
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	35
http://linked.open...iv/tvurceVysledku	Kováčová, Zuzana Polák, Jan Šiklová-Vítková, Michaela Štich, Vladimír Bajzová, Magda Hejnová, Jindřiška Hněvkovská, Zuzana Klimčáková, Eva Kováčiková, Michaela Rossmeislová, Lenka
http://linked.open...ain/vavai/riv/wos	000286094900012
issn	0307-0565
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1038/ijo.2010.112
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women

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