About: How Valid Are the Rates of Down Syndrome Internationally? Findings from the International Clearinghouse for Birth Defects Surveillance and Research

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About: How Valid Are the Rates of Down Syndrome Internationally? Findings from the International Clearinghouse for Birth Defects Surveillance and Research Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1002/ajmg.a.33493
Description	Rates of Down syndrome (DS) show considerable international variation, but a systematic assessment of this variation is lacking. The goal of this study was to develop and test a method to assess the validity of DS rates in surveillance programs, as an indicator of quality of ascertainment. The proposed method compares the observed number of cases with DS (livebirths plus elective pregnancy terminations, adjusted for spontaneous fetal losses that would have occurred if the pregnancy had been allowed to continue) in each single year of maternal age, with the expected number of cases based on the best-published data on rates by year of maternal age. To test this method we used data from birth years 2000 to 2005 from 32 surveillance programs of the International Clearinghouse for Birth Defects Surveillance and Research. We computed the adjusted observed versus expected ratio (aOE) of DS birth prevalence among women 25-44 years old. The aOE ratio was close to unity in 13 programs (the 95% confidence interv Rates of Down syndrome (DS) show considerable international variation, but a systematic assessment of this variation is lacking. The goal of this study was to develop and test a method to assess the validity of DS rates in surveillance programs, as an indicator of quality of ascertainment. The proposed method compares the observed number of cases with DS (livebirths plus elective pregnancy terminations, adjusted for spontaneous fetal losses that would have occurred if the pregnancy had been allowed to continue) in each single year of maternal age, with the expected number of cases based on the best-published data on rates by year of maternal age. To test this method we used data from birth years 2000 to 2005 from 32 surveillance programs of the International Clearinghouse for Birth Defects Surveillance and Research. We computed the adjusted observed versus expected ratio (aOE) of DS birth prevalence among women 25-44 years old. The aOE ratio was close to unity in 13 programs (the 95% confidence interv (en)
Title	How Valid Are the Rates of Down Syndrome Internationally? Findings from the International Clearinghouse for Birth Defects Surveillance and Research How Valid Are the Rates of Down Syndrome Internationally? Findings from the International Clearinghouse for Birth Defects Surveillance and Research (en)
skos:prefLabel	How Valid Are the Rates of Down Syndrome Internationally? Findings from the International Clearinghouse for Birth Defects Surveillance and Research How Valid Are the Rates of Down Syndrome Internationally? Findings from the International Clearinghouse for Birth Defects Surveillance and Research (en)
skos:notation	RIV/00216208:11120/10:00003111!RIV12-MSM-11120___
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Šípek, Antonín
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	262206
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/10:00003111
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Down syndrome; epidemiology; prevalence; validity; registries (en)
http://linked.open.../riv/klicoveSlovo	registries epidemiology prevalence Down syndrome validity
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[83EC79E06BDB]
http://linked.open...i/riv/nazevZdroje	American Journal of Medical Genetics Part A
http://linked.open...in/vavai/riv/obor	FK
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	31 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	152A
http://linked.open...iv/tvurceVysledku	Šípek, Antonín Leoncini, Emanuele
http://linked.open...ain/vavai/riv/wos	000280115000038
issn	1552-4825
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/ajmg.a.33493
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	How Valid Are the Rates of Down Syndrome Internationally? Findings from the International Clearinghouse for Birth Defects Surveillance and Research How Valid Are the Rates of Down Syndrome Internationally? Findings from the International Clearinghouse for Birth Defects Surveillance and Research

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