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  • Adipokines play a significant role in the pathogenesis of a low-grade inflammation associated with obesity and metabolic syndrome, and in chronic inflammatory and autoimmune diseases such as rheumatoid arthritis. Among variety of adipokines, resistin and visfatin are proposed as important pro-inflammatory mediators, which also interfere with the central regulation of insulin sensitivity. Resistin has been initially postulated as a risk factor for insulin resistance, however, the subsequent available data on it have revealed contradictory findings in both humans and rodents. On the other hand, visfatin has been suggested to be a beneficial adipokine with insulin-mimicking/-sensitizing effects, but regulation of visfatin production and its physiological importance in the conditions of obesity and type 2 diabetes mellitus are still not completely understood. Despite the opposing effects of resistin and visfatin on the regulation of insulin sensitivity, both adipokines have pro-inflammatory properties. Cl
  • Adipokines play a significant role in the pathogenesis of a low-grade inflammation associated with obesity and metabolic syndrome, and in chronic inflammatory and autoimmune diseases such as rheumatoid arthritis. Among variety of adipokines, resistin and visfatin are proposed as important pro-inflammatory mediators, which also interfere with the central regulation of insulin sensitivity. Resistin has been initially postulated as a risk factor for insulin resistance, however, the subsequent available data on it have revealed contradictory findings in both humans and rodents. On the other hand, visfatin has been suggested to be a beneficial adipokine with insulin-mimicking/-sensitizing effects, but regulation of visfatin production and its physiological importance in the conditions of obesity and type 2 diabetes mellitus are still not completely understood. Despite the opposing effects of resistin and visfatin on the regulation of insulin sensitivity, both adipokines have pro-inflammatory properties. Cl (en)
Title
  • Resistin and visfatin: regulators of insulin sensitivity, inflammation and immunity
  • Resistin and visfatin: regulators of insulin sensitivity, inflammation and immunity (en)
skos:prefLabel
  • Resistin and visfatin: regulators of insulin sensitivity, inflammation and immunity
  • Resistin and visfatin: regulators of insulin sensitivity, inflammation and immunity (en)
skos:notation
  • RIV/00216208:11120/10:00002576!RIV11-MSM-11120___
http://linked.open...avai/riv/aktivita
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  • Z(MSM0021620816)
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  • 285003
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  • RIV/00216208:11120/10:00002576
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  • resistin; visfatin; obesity; insulin resistance; inflammation; autoimmunity; atherosclerosis; arthritis (en)
http://linked.open.../riv/klicoveSlovo
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  • SK - Slovenská republika
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  • [A56A453F60D2]
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  • Endocrine Regulations
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  • 44
http://linked.open...iv/tvurceVysledku
  • Štofková, Andrea
http://linked.open...n/vavai/riv/zamer
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  • 1210-0668
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  • 11120
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