About: Similar Effects of Lamotrigine and Phenytoin against Cortical Epileptic Foci in Immature Rats

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Action of antiepileptic drugs in immature brain may differ from that in adult brain. The aim of our study was to study an anticonvulsant action of lamotrigine and phenytoin, i.e. two drugs active against partial seizures in adult experimental animals as well as human patients, in a model of simple partial seizures in immature rats. Epileptic foci were induced by local application of bicuculline methiodide on sensorimotor cortical area of 12-day-old rat pups. The animals were pretreated with lamotrigine (LTG, 10 or 20 mg/kg i.p.) or phenytoin (PHT, 15, 30 or 60 mg/kg i.p.). Control rats for LTG received saline, controls for PHT solvent composed of propyleneglycol, ethanol and water. Influence of either drug on interictal activity was negligible. High doses of both LTG and PHT suppressed the transition into ictal phases and shortened the duration of persisting seizures. The tricomponent solvent exhibited moderate activity against ictal activity if compared with saline controls. The two drugs exhibited s Action of antiepileptic drugs in immature brain may differ from that in adult brain. The aim of our study was to study an anticonvulsant action of lamotrigine and phenytoin, i.e. two drugs active against partial seizures in adult experimental animals as well as human patients, in a model of simple partial seizures in immature rats. Epileptic foci were induced by local application of bicuculline methiodide on sensorimotor cortical area of 12-day-old rat pups. The animals were pretreated with lamotrigine (LTG, 10 or 20 mg/kg i.p.) or phenytoin (PHT, 15, 30 or 60 mg/kg i.p.). Control rats for LTG received saline, controls for PHT solvent composed of propyleneglycol, ethanol and water. Influence of either drug on interictal activity was negligible. High doses of both LTG and PHT suppressed the transition into ictal phases and shortened the duration of persisting seizures. The tricomponent solvent exhibited moderate activity against ictal activity if compared with saline controls. The two drugs exhibited s (en)
Title	Similar Effects of Lamotrigine and Phenytoin against Cortical Epileptic Foci in Immature Rats Similar Effects of Lamotrigine and Phenytoin against Cortical Epileptic Foci in Immature Rats (en)
skos:prefLabel	Similar Effects of Lamotrigine and Phenytoin against Cortical Epileptic Foci in Immature Rats Similar Effects of Lamotrigine and Phenytoin against Cortical Epileptic Foci in Immature Rats (en)
skos:notation	RIV/00216208:11120/10:00002400!RIV11-GA0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS501210509), P(GA305/05/2581), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Bernášková, Klára
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	287317
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/10:00002400
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cerebral cortex; Epileptic focus; Bicuculline methiodide; Immature rat; Antiepileptic drugs (en)
http://linked.open.../riv/klicoveSlovo	Antiepileptic drugs Cerebral cortex Bicuculline methiodide Epileptic focus Immature rat
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[CDA413C98060]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Optical mapping of brain activity Developmental pharmakology of GABA-B systém: its role in epilepsy,cognition and pain
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Mareš, Pavel Bernášková, Klára
http://linked.open...ain/vavai/riv/wos	000276097000014
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0862-8408
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Similar Effects of Lamotrigine and Phenytoin against Cortical Epileptic Foci in Immature Rats Similar Effects of Lamotrigine and Phenytoin against Cortical Epileptic Foci in Immature Rats Similar Effects of Lamotrigine and Phenytoin against Cortical Epileptic Foci in Immature Rats

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