About: Multicentric Validation of Proteomic Biomarkers in Urine Specific for Diabetic Nephropathy

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Urine proteome analysis is rapidly emerging as a tool for diagnosis and prognosis in disease states. For diagnosis of diabetic nephropathy (DN), urinary proteome analysis was successfully applied in a pilot study. The validity of the previously established proteomic biomarkers with respect to the diagnostic and prognostic potential was assessed on a separate set of patients recruited at three different European centers. In this case-control study of 148 Caucasian patients with diabetes mellitus type 2 and duration >= 5 years, cases of DN were defined as albuminuria >300 mg/d and diabetic retinopathy (n = 66). Controls were matched for gender and diabetes duration (n = 82). Conclusions: These data provide the first independent confirmation that profiling of the urinary proteome by CE-MS can adequately identify subjects with DN, supporting the generalizability of this approach. The data further establish urinary collagen fragments as biomarkers for diabetes-induced renal damage that may serve as e Urine proteome analysis is rapidly emerging as a tool for diagnosis and prognosis in disease states. For diagnosis of diabetic nephropathy (DN), urinary proteome analysis was successfully applied in a pilot study. The validity of the previously established proteomic biomarkers with respect to the diagnostic and prognostic potential was assessed on a separate set of patients recruited at three different European centers. In this case-control study of 148 Caucasian patients with diabetes mellitus type 2 and duration >= 5 years, cases of DN were defined as albuminuria >300 mg/d and diabetic retinopathy (n = 66). Controls were matched for gender and diabetes duration (n = 82). Conclusions: These data provide the first independent confirmation that profiling of the urinary proteome by CE-MS can adequately identify subjects with DN, supporting the generalizability of this approach. The data further establish urinary collagen fragments as biomarkers for diabetes-induced renal damage that may serve as e (en)
Title	Multicentric Validation of Proteomic Biomarkers in Urine Specific for Diabetic Nephropathy Multicentric Validation of Proteomic Biomarkers in Urine Specific for Diabetic Nephropathy (en)
skos:prefLabel	Multicentric Validation of Proteomic Biomarkers in Urine Specific for Diabetic Nephropathy Multicentric Validation of Proteomic Biomarkers in Urine Specific for Diabetic Nephropathy (en)
skos:notation	RIV/00216208:11120/10:00002393!RIV11-MSM-11120___
http://linked.open...avai/riv/aktivita	R Z
http://linked.open...avai/riv/aktivity	R, Z(MSM0021620814)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Medek, Karel Rychlík, Ivan Černá, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	273059
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/10:00002393
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Chronic Kidney Disease; proteins (en)
http://linked.open.../riv/klicoveSlovo	Chronic Kidney Disease proteins
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6A7AF559E5F3]
http://linked.open...i/riv/nazevZdroje	Plos One
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	18 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Rychlík, Ivan Černá, Marie Medek, Karel
http://linked.open...ain/vavai/riv/wos	000283216400005
http://linked.open...n/vavai/riv/zamer	Prevention, diagnostics and therapy of diabetes mellitus, metabolic and endocrine damage of organism
issn	1932-6203
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Multicentric Validation of Proteomic Biomarkers in Urine Specific for Diabetic Nephropathy Multicentric Validation of Proteomic Biomarkers in Urine Specific for Diabetic Nephropathy Multicentric Validation of Proteomic Biomarkers in Urine Specific for Diabetic Nephropathy

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