About: Effect of Prenatal and Postnatal Methamphetamine Exposure on Nociception in Adult Female Rats

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of the present study was to determine effects of methamphetamine (MA) exposure and cross-fostering on thermal nociceptive thresholds in different estrous phases in adult female rats. Rat mothers were exposed daily to injection of MA (5 mg/kg) or saline for 9 weeks: prior to impregnation, throughout gestation and lactation periods. Dams without any injections were used as all absolute control. On postnatal day 1, pups were cross-fostered so that each mother raised four pups of her own and eight pups from the mothers with the other two treatments. Offspring females were tested in adulthood (85-90 days) for thermal nociception as latency [s] of withdrawal reaction of forelimbs, hind limbs, and tail. Our results showed that prenatal MA exposure did not affect the nociception in adulthood, while postnatal MA exposure (i.e., MA administration to lactating mothers) had pro-nociceptive effects. The affect of postnatal MA exposure was apparent in both, fore- and hind limbs, while the latency to tail wi The aim of the present study was to determine effects of methamphetamine (MA) exposure and cross-fostering on thermal nociceptive thresholds in different estrous phases in adult female rats. Rat mothers were exposed daily to injection of MA (5 mg/kg) or saline for 9 weeks: prior to impregnation, throughout gestation and lactation periods. Dams without any injections were used as all absolute control. On postnatal day 1, pups were cross-fostered so that each mother raised four pups of her own and eight pups from the mothers with the other two treatments. Offspring females were tested in adulthood (85-90 days) for thermal nociception as latency [s] of withdrawal reaction of forelimbs, hind limbs, and tail. Our results showed that prenatal MA exposure did not affect the nociception in adulthood, while postnatal MA exposure (i.e., MA administration to lactating mothers) had pro-nociceptive effects. The affect of postnatal MA exposure was apparent in both, fore- and hind limbs, while the latency to tail wi (en)
Title	Effect of Prenatal and Postnatal Methamphetamine Exposure on Nociception in Adult Female Rats Effect of Prenatal and Postnatal Methamphetamine Exposure on Nociception in Adult Female Rats (en)
skos:prefLabel	Effect of Prenatal and Postnatal Methamphetamine Exposure on Nociception in Adult Female Rats Effect of Prenatal and Postnatal Methamphetamine Exposure on Nociception in Adult Female Rats (en)
skos:notation	RIV/00216208:11120/10:00001954!RIV10-MZ0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1A8610), P(LC554), Z(MSM0021620816)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hrubá, Lenka Šlamberová, Romana Vaculín, Šimon
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	256113
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/10:00001954
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	methamphetamine; nociception; cross-fostering; estrous cycle (en)
http://linked.open.../riv/klicoveSlovo	estrous cycle methamphetamine cross-fostering nociception
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D6831C45373B]
http://linked.open...i/riv/nazevZdroje	Developmental Psychobiology
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Factors affecting healthy development of progeny of drug-abusing mothers Neuroscience Centre
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Hrubá, Lenka Šlamberová, Romana Vaculín, Šimon
http://linked.open...ain/vavai/riv/wos	000273621700008
http://linked.open...n/vavai/riv/zamer	Název: Patofyziologie neuropsychiatrických onemocnění a její klinické aplikace
issn	0012-1630
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Effect of Prenatal and Postnatal Methamphetamine Exposure on Nociception in Adult Female Rats Effect of Prenatal and Postnatal Methamphetamine Exposure on Nociception in Adult Female Rats Effect of Prenatal and Postnatal Methamphetamine Exposure on Nociception in Adult Female Rats

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