About: Effect of methamphetamine exposure and cross-fostering on cognitive function in adult male rats

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of our study was to examine the effect of prenatal methamphetamine (MA) exposure and cross-fostering on cognitive functions of adult male rats tested in Morris water maze (MWM). Rat mothers were exposed daily to injection of MA (5 mg/kg) or saline for 9 weeks: prior to impregnation, throughout gestation and lactation periods. Females without any injections were used as an absolute control. On postnatal day 1, pups were cross-fostered so that each mother raised 4 pups of her own and 8 pups from the mothers with the other two treatments. Four types of tests were used: (1) Place navigation test (Learning), (2) Probe test (Probe), (3) Retention memory test (Memory) and (4) Visible platform task. Our results demonstrate that the prenatal exposure to MA does not impact learning and memory, while postnatal exposure to MA shows impairments in cognition. In the test of learning, all animals fostered to MA-treated dams had longer latencies, bigger search error and used lower spatial strategies than the The aim of our study was to examine the effect of prenatal methamphetamine (MA) exposure and cross-fostering on cognitive functions of adult male rats tested in Morris water maze (MWM). Rat mothers were exposed daily to injection of MA (5 mg/kg) or saline for 9 weeks: prior to impregnation, throughout gestation and lactation periods. Females without any injections were used as an absolute control. On postnatal day 1, pups were cross-fostered so that each mother raised 4 pups of her own and 8 pups from the mothers with the other two treatments. Four types of tests were used: (1) Place navigation test (Learning), (2) Probe test (Probe), (3) Retention memory test (Memory) and (4) Visible platform task. Our results demonstrate that the prenatal exposure to MA does not impact learning and memory, while postnatal exposure to MA shows impairments in cognition. In the test of learning, all animals fostered to MA-treated dams had longer latencies, bigger search error and used lower spatial strategies than the (en)
Title	Effect of methamphetamine exposure and cross-fostering on cognitive function in adult male rats Effect of methamphetamine exposure and cross-fostering on cognitive function in adult male rats (en)
skos:prefLabel	Effect of methamphetamine exposure and cross-fostering on cognitive function in adult male rats Effect of methamphetamine exposure and cross-fostering on cognitive function in adult male rats (en)
skos:notation	RIV/00216208:11120/10:00001926!RIV10-MZ0-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1A8610), P(LC554), Z(MSM0021620816)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Schutová, Barbora Pometlová, Marie Hrubá, Lenka Šlamberová, Romana Rokyta, Richard
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	256057
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/10:00001926
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cognitive functions; cross-fostering; methamphetamine (en)
http://linked.open.../riv/klicoveSlovo	methamphetamine cognitive functions cross-fostering
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[5BC78ABEA5B8]
http://linked.open...i/riv/nazevZdroje	Behavioural Brain Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Factors affecting healthy development of progeny of drug-abusing mothers Neuroscience Centre
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	208
http://linked.open...iv/tvurceVysledku	Hrubá, Lenka Pometlová, Marie Rokyta, Richard Schutová, Barbora Šlamberová, Romana
http://linked.open...ain/vavai/riv/wos	000275625100008
http://linked.open...n/vavai/riv/zamer	Název: Patofyziologie neuropsychiatrických onemocnění a její klinické aplikace
issn	0166-4328
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Effect of methamphetamine exposure and cross-fostering on cognitive function in adult male rats Effect of methamphetamine exposure and cross-fostering on cognitive function in adult male rats Effect of methamphetamine exposure and cross-fostering on cognitive function in adult male rats

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