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  • Since the 1950s, lithium salts have been the main line of treatment for bipolar disorder (BD), both as a prophylactic and as an episodic treatment agent. Like many psychiatric conditions, BD is genetically and phenotypically heterogeneous, but evidence suggests that individuals who respond well to lithium treatment have more homogeneous clinical and molecular profiles. Response to lithium seems to cluster in families and can be used as a predictor for recurrence of BD symptoms. While molecular studies have provided important information about possible genes involved in BD predisposition or in lithium response, neither the mechanism of action of this drug nor the genetic profile of bipolar disorder is, as yet, completely understood.
  • Since the 1950s, lithium salts have been the main line of treatment for bipolar disorder (BD), both as a prophylactic and as an episodic treatment agent. Like many psychiatric conditions, BD is genetically and phenotypically heterogeneous, but evidence suggests that individuals who respond well to lithium treatment have more homogeneous clinical and molecular profiles. Response to lithium seems to cluster in families and can be used as a predictor for recurrence of BD symptoms. While molecular studies have provided important information about possible genes involved in BD predisposition or in lithium response, neither the mechanism of action of this drug nor the genetic profile of bipolar disorder is, as yet, completely understood. (en)
Title
  • Lithium: a key to the genetics of bipolar disorder
  • Lithium: a key to the genetics of bipolar disorder (en)
skos:prefLabel
  • Lithium: a key to the genetics of bipolar disorder
  • Lithium: a key to the genetics of bipolar disorder (en)
skos:notation
  • RIV/00216208:11120/09:43908364!RIV14-MSM-11120___
http://linked.open...avai/riv/aktivita
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  • N
http://linked.open...iv/cisloPeriodika
  • 8, Art. ID 79
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 323939
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  • RIV/00216208:11120/09:43908364
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • bipolar disorder; genetics; Lithium (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [A0B16F0FB630]
http://linked.open...i/riv/nazevZdroje
  • Genome Medicine
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http://linked.open...UplatneniVysledku
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  • 1
http://linked.open...iv/tvurceVysledku
  • Alda, Martin
  • Cruceanu, Cristiana
  • Turecki, Gustavo
http://linked.open...ain/vavai/riv/wos
  • 000208627000079
issn
  • 1756-994X
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  • 11120
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